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. 2018 Jul 13;7:e37439. doi: 10.7554/eLife.37439

Figure 2. Representative operon structures/gene clusters from organisms containing hdr-like and lbpA genes.

Homologous genes are colored the same between organisms. Genes in white are not conserved between the groups. The Kegg/NCBI locus tag identifiers for the first and last genes are shown below each cluster. GATase1, glutamine amidotransferase class I; DsrE, -E2, -E3A, DsrE-like sulfurtransferases (Dahl, 2015); Rhd, rhodanese-like sulfurtransferase (Bordo and Bork, 2002); Hyp, hypothetical protein; TusA, TusA-like sulfur carrier protein (Dahl, 2015; Dahl et al., 2013); CCG domain, domain with CCG signature motif of non-cubane [4Fe-4S] cluster-binding heterodisulfide reductase active sites (Wagner et al., 2017); Etf, electron-transferring flavoprotein (Garcia Costas et al., 2017).

Figure 2—source data 1. Occurrence of hdr-like, lbpA and lbpA maturation genes in genome-sequenced prokaryotes.
elife-37439-fig2-data1.docx (132.1KB, docx)
DOI: 10.7554/eLife.37439.005

Figure 2.

Figure 2—figure supplement 1. Sequence alignment of Hdr-associated lipoate-binding proteins from seven archaeal and bacterial phyla.

Figure 2—figure supplement 1.

The strictly conserved lipoate-binding lysine residue shared with the H proteins of the glycine-cleavage system is indicated by red arrows. Strictly conserved residues are marked with yellow boxes. Strictly conserved cysteine residues are highlighted by red boxes. Species: Metallosphaera cuprina Ar4T (Mcup_0662 (AEB947679)) Acidimicrobium ferrooxidans DSM 10331T (Afer_0973 (Acu53912), Afer_0974 (ACU53913)), Thermomicrobium roseum DSM 5159T (Trd_0143 (ACM05628), Trd_0144 (ACM04497)), Hydrogenobacter thermophiles (HTH_RS09400 (HTH_1874, BAI70318), HTH_RS09415 (HTH_1877, BAI70321), Kyrpidia tusciae DSM 2912T(Btus_2489 (ADG07149), Btus_2490 (ADG07150)), Thiorohdospira sibirica ATCC 700588T (ThisiDRAFT_1533 (EGZ46119)), Acidithiobacillus caldus SM-1 (Atc_2344 (AEK58992), Atc_2346 (AEK58994)), Thioalkalivibrio sp. K90mix (TK90_0638 (ADC71153), TK_0640 (ADC71155)), Chloroherpeton thalassium ATCC 35110T (Ctha_0140 (ACF12611)), Hyphomicrobium denitrificans ATCC 51888T (Hden_0696 (ADJ22516)), Sulfuricella denitrificans DSM 22764T (SCD_RS03985 (SCD_01710, BAN34642)). Proteobac., Proteobacteria.