Figure 1.

Microtubule-dependent and centrosome-oriented transport of centriolar satellites. (A) Schematic representation of centriolar satellite (CS) transport. CS gravitate around the centrosome and are connected to the microtubule network through microtubule-associated motor proteins. These motor proteins facilitate the stepwise movement of centriolar satellites towards (retrograde) or away from (anterograde) the centrosome; (B) Reconstructed 3D-Structured Illumination Microscopy (3D-SIM) images of centriolar satellites in interphase U2OS cells. Centriolar satellites are visualized by PCM1 staining (green), the centrosome is visualized by pericentrin (red) staining and the nucleus (DAPI) in blue.