Table 1. Cytotoxic activity IC50* of the triphenylphosphonium betulinic and ursolic acid derivatives against the cancer cells TET21N and MCF-7.
Test compound | TET21N | MCF-7 |
6 | 1.26 ± 0.18 | 0.80 ± 0.08 |
7 | 0.98 ± 0.11 | 0.85 ± 0.09 |
8 | 1.28 ± 0.18 | 1.51 ± 0.13 |
9 | 0.74 ± 0.14 | 0.70 ± 0.11 |
10 | 0.95 ± 0.15 | 2.31 ± 0.09 |
14 | 4.4 ± 0.34 | 2.76 ± 0.21 |
15 | 0.81 ± 0.08 | 1.59 ± 0.11 |
16 | 1.18 ± 0.16 | 3.90 ± 0.06 |
BA-DCA | 4.9 ± 0.2 | 15.89 ± 0.19 |
UA-DCA | >10 | >20 |
BA | — | >25 |