Fig. 3. ICM docking scores of SCFSkp2 inhibitors. The dotted line represents the putative threshold ICM docking score predictive of binding (≤–32). C1 and C2 were docked to their corresponding Skp2–P–p27 pocket. NSC689857 and compound A were docked to the Skp2–Skp1 interface with no originally identifiable pocket. 22d and NSC689857 were docked to the Skp2–Cks1 interface pocket. Both linichlorin A and gentian violet were docked to the Skp2–P–p27 and the Skp2–Cks1 pockets. Superscript 1 denotes docking to the Skp2–P–p27 pocket and superscript 2 denotes docking to the Skp2–Cks1 pocket.
