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. 2018 Jul 17;9(55):30635–30648. doi: 10.18632/oncotarget.25761

Figure 5. Role of P2X7R-expression on the hematopoietic system in LPS-induced lung inflammation.

Figure 5

The different BM chimera animals were exposed to LPS. 24 hours later animals were killed and BALF was analyzed by flow cytometry. Cytokine levels were determined by ELISA. (A) Significant decrease of neutrophils and macrophages in BALF of P2X7R−/− animals and WT mice with a lack of P2X7R expression in the hematopoietic system compared to WT mice. (B) No effect on IL-1β-levels. Significant reduction of IL-6 levels only in WT mice with a lack of P2X7R expression in the hematopoietic system and of KC only in P2X7R−/− animals. Significant MIP-2 and TNF-α reduction in all P2X7R−/− chimera with largest effects in WT mice with a lack of P2X7R expression in the hematopoietic system and complete P2X7R−/− animals. *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle/LPS.