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. 2018 Jul 18;145(14):dev164459. doi: 10.1242/dev.164459

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© 2018. Published by The Company of Biologists Ltd

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Fig. 1. — Requirement for SOX9 in precartilaginous condensation. (A,B) H&E staining of hindlimb bud sections from E11.5 Sox9^fl/− and Sox9^−/− (A), and E12.5 Sox9^fl/fl and Sox9^fl/flPrx1CreER embryo littermates (B). Arrow, digit 3 PC. (C) Visualization of the actin cytoskeleton in E12.5 Sox9^flfl and Sox9^flflPrx1CreER mouse limb buds. Sections were stained for SOX9 (red), F-actin (green) and DNA (blue). (Ca,f) Low-magnification images of limb buds. (Cb-d,g-i) High-magnification images within actual (Sox9^fl/fl) and failed (Sox9^fl/flPrx1CreER) PCs. (Ce,Cj) Images within actual and presumptive interdigital mesenchyme. (Cb-e,g-j) Top panels, merged images for SOX9, F-actin and DNA; bottom panels, F-actin.