Fig. 7.

Effects of MEPH, 4 MM, and MeCa ± L-DOPA, PARG, or METH on core body temperature. Core body temperatures of mice treated with 4 MM (A), MeCa (B), MEPH (C), ± L-DOPA, pargyline (PARG), or METH were recorded every 20 min. MEPH, 4 MM, MeCa, and METH were administered at time points 40, 160, 280, and 400 min. L-DOPA and PARG were administered 20 min prior to time point 0, and L-DOPA was also administered at time points 100, 220, and 340 min. Data are presented as mean temperature in C. SEMs were <5% of the mean for each group and are omitted for clarity. L-DOPA, PARG, and METH controls were run with each experiment and included for analysis, but each is included on only one graph for clarity. Significance versus controls (p < 0.05) is indicated with open symbols. Data for MEPH + METH from Angoa-Perez et al. (2013) were reprinted for comparison, with permission from John Wiley and Sons, Inc. These were not analyzed in the present figure, but induced a significant hyperthermia compared to controls in the original publication. N = 4–9 mice per group.