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. 2001 Apr 4;1:114–116. doi: 10.1100/tsw.2001.17

Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays

Karoly Mirnics 1, Frank A Middleton 1, David A Lewis 1, Pat Levitt 1,*
PMCID: PMC6084111  PMID: 12805694

Abstract

Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.

Keywords: schizophrenia, profrontal cortex, synaptic function, neurosecretion, G-proteins, gene microarrays, polygenic disorders, neurodevelopment


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