Correction: AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

In Fig 1 panel A, the data sets of the control groups (Aim2^-/- Dnase2^+/+ Ifnar1^-/- and Aim2^+/+ Dnase2^+/+ Ifnar1^-/-) are shown as mirror images of the original data. In Fig 2 panel A, the shades of grey in the legend (Aim2^-/- Dnase2^+/+ Ifnar1^-/- and Aim2^+/+ Dnase2^+/+ Ifnar1^-/-) are swapped. In Fig 2 panel B the third and fourth labels are swapped. Please see the correct Figs 1 and 2 here.

Fig 1. Swelling of joints in the context of Dnase2-deficiency is AIM2-dependent.

A: Aim2^+/+ Dnase2^-/- Ifnar1^-/-, Aim2^-/- Dnase2^-/- Ifnar1^-/-, Aim2^+/+ Dnase2^+/+ Ifnar1^-/- and Aim2^-/- Dnase2^+/+ Ifnar1^-/- mice were scored for joint swelling at indicated time points in a blinded fashion. Statistical significance was assessed using a two-tailed Mann-Whitney test comparing Dnase2^-/- cohorts at 8, 12 or 15 months. B: Representative pictures of fore-and hind pads of Aim2^+/+ Dnase2^-/- Ifnar1^-/-, Aim2^-/- Dnase2^-/- Ifnar1^-/-, Aim2^+/+ Dnase2^+/+ Ifnar1^-/- and Aim2^-/- Dnase2^+/+ Ifnar1^-/- mice at the age of 15 month are shown.

Fig 2. Systemic proinflammatory status in Dnase2^-/- mice is independent of AIM2.

A: Serum was collected from Aim2^+/+ Dnase2^-/- Ifnar1^-/-, Aim2^-/- Dnase2^-/- Ifnar1^-/-, Aim2^+/+ Dnase2^+/+ Ifnar1^-/- and Aim2^-/- Dnase2^+/+ Ifnar1^-/- mice at the age of 15 month and analyzed for the depicted cytokines. B: Spleen weight and representative pictures of spleens from mice at the age of 15 month. C: Relative IFNβ gene expression in spleen tissue normalized to the expression level of HPRT1 is shown. D: Anti-cyclic citrullinated peptide antibody (Anti-CCP-AB) was measured in serum samples as in (A). Data are presented as mean values + SEM, whereas statistical significance was assessed using a two-tailed, unpaired t-test comparing the Dnase2^-/- cohorts.