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. 2018 Jul 24;13:4. doi: 10.1016/j.idcr.2018.e00428

Talaromyces (Penicillium) marneffei infection

Qian Du 1,, Chak Kwan Tong 1
PMCID: PMC6088560  PMID: 30116714

Abstract

A 41-year-old man from the emergency department presented with fever for 2 weeks, sore throat, dry cough and generalized umbilicated skin lesions (face (Fig. 1), and chest (Fig. 2)). HIV antibody was positive, CD4+ count was 2/μL. His skin swab, sputum and blood culture all yielded Talaromyces (Penicillium) marneffei (Fig. 3).

Talaromyces marneffei is an important cause of morbidity and mortality in HIV-infected and other immunosuppressed patients who live in or are from endemic areas especially Southeast Asia. Amphotericin B or Itraconazole should be initiated as soon as possible for patients with talaromycosis.

Keywords: Talaromyces marneffei, Infection, HIV


A 41-year-old man admitted from the emergency department, presented with fever for 2 weeks, sore throat, dry cough and generalized umbilicated skin lesions (face (Fig. 1), and chest (Fig. 2)). HIV antibody was positive, CD4+ count was 2 /μL. His skin swab, sputum and blood culture all yielded Talaromyces (Penicillium) marneffei (Fig. 3).

Fig. 1.

Fig. 1

Umbilicated skin lesions on the face.

Fig. 2.

Fig. 2

Umbilicated skin lesions on the chest.

Fig. 3.

Fig. 3

Colonies of Talaromyces (Penicillium) marneffei.

Talaromyces marneffei is an important cause of morbidity and mortality in HIV-infected and other immunosuppressed patients who live in or are from endemic areas especially Southeast Asia [1]. Amphotericin B or Itraconazole should be initiated as soon as possible for patients with talaromycosis [2].

References

  • 1.Walsh T.J., Groll A. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect. 2004;10(Suppl. 1):48. doi: 10.1111/j.1470-9465.2004.00839.x. [DOI] [PubMed] [Google Scholar]
  • 2.Sirisanthana T., Supparatpinyo K. Amphotericin B and itraconazole for treatment of disseminated Penicillium marneffei infection in human immunodeficiency virus-infected patients. Clin Infect Dis. 1998;26(5):1107. doi: 10.1086/520280. [DOI] [PubMed] [Google Scholar]

Articles from IDCases are provided here courtesy of Elsevier

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