Table 1.
Patient demographic, clinical and tumor characteristics
| Overall Cohort | 3D | IMRT | Chi-sq P | |
|---|---|---|---|---|
| N = 2553 (100%) | N=2240(100%) | N=313 (100%) | ||
| Age | ||||
| 66-70 | 729(28.6) | 634(28.3) | 95(30.4) | 0.7698 |
| 71-75 | 669(26.2) | 584(26.1) | 85(27.2) | |
| 76-80 | 560(21.9) | 496(22.1) | 64(20.5) | |
| >80 | 595(23.3) | 526(23.5) | 69(22.0) | |
| Years of Diagnosis | ||||
| 2002-2003 | 695(27.2) | 672(30) | 23(7.4) | <.0001 |
| 2004 | 369(14.5) | 351(15.7) | 18(5.8) | |
| 2005 | 313(12.3) | 284(12.7) | 29(9.3) | |
| 2006 | 349(13.7) | 302(13.5) | 47(15.0) | |
| 2007 | 362(14.2) | 287(12.8) | 75(24.0) | |
| 2008 | 216(8.7) | 171(7.6) | 45(14.4) | |
| 2009 | 249(9.8) | 173(7.7) | 76(24.3) | |
| Marital Status | ||||
| Married | 1230(48.2) | 1097(49.0) | 133(42.5) | 0.0403 |
| Not married | 771(30.2) | 674(30.1) | 97(31.0) | |
| Unknown* | 552(21.6) | 469(20.9) | 83(26.5) | |
| Histology | ||||
| Adeno | 1423(55.7) | 1255(56.0) | 168(53.7) | 0.4325 |
| SCCA | 1130(44.3) | 985(44.0) | 145(46.3) | |
| Race/Ethnicity | ||||
| White | 2095(82.1) | 1834(81.9) | 261(83.4) | 0.0619 |
| Hispanic | 144(5.6) | 120(5.4) | 24(7.7) | |
| Black/Other | 314(12.3) | 286(12.8) | 28(9.0) | |
| Stage | ||||
| Localized | 991(38.8) | 862(38.5) | 129(41.2) | 0.3529 |
| Regional | 1562(61.2) | 1378(61.5) | 184(58.8) | |
| Gender | ||||
| Female | 744(29.1) | 657(29.3) | 87(27.8) | 0.5757 |
| Male | 1809(70.9) | 1583(70.7) | 226(72.2) | |
| Patients receiving Surgery After Radiation Treatment | ||||
| No | 2107(82.5) | 1855(82.81) | 252(80.5) | 0.3152 |
| Yes | 446(17.5) | 385(17.19) | 61(19.5) | |
| Tumor Grade | ||||
| Well differentiated | 123(4.8) | 108(4.8) | 15(4.8) | 0.9662 |
| Moderately differentiated | 957(37.5) | 839(37.5) | 118(37.7) | |
| Poorly differentiated | 1033(40.5) | 910(40.6) | 123(39.3) | |
| Unknown | 440(17.2) | 383(17.1) | 57(18.2) | |
| Charlson Score | ||||
| 0 | 1510(59.2) | 1313(58.6) | 197(62.9) | 0.2957 |
| 1 | 664(26.0) | 593(26.5) | 71(22.7) | |
| 2+ | 379(14.9) | 334(14.9) | 45(14.34) | |
| Regions (SEER + Texas) | ||||
| California + Hawaii | 563(22.1) | 484(21.6) | 79(25.2) | 0.0632 |
| 6 SEER regions combined** | 636(24.9) | 576(25.7) | 60(19.2) | |
| Greater Georgia | 256(10.0) | 232(10.4) | 24(7.7) | |
| Kentucky | 161(6.3) | 141(6.3) | 20(6.4) | |
| Louisiana | 134(5.3) | 116(5.2) | 18(5.8) | |
| New Jersey | 324(12.7) | 284(12.7) | 40(12.8) | |
| Texas | 479(18.8) | 407(18.2) | 72(23) | |
| Use of Chemotherapy | 0.0881 | |||
| No | 411(16.1) | 371(16.6) | 40(12.8) | |
| Yes | 2142(83.9) | 1869(83.4) | 273(87.2) | |
| Urban/Rural | ||||
| Big Metro | 1285(50.3) | 1124(50.2) | 161(51.4) | 0.5954 |
| Less Urban/Rural | 411(16.1) | 369(16.5) | 42(13.4) | |
| Metro | 805(31.5) | 701(31.3) | 104(33.2) | |
| Urban | 168(6.6) | 148(6.6) | 20(6.4) | |
| % of adults with <12 y of Education | ||||
| Lowest Quartile | 625(24.5) | 544(24.3) | 81(25.9) | 0.627 |
| 2nd Quartile | 607(23.8) | 529(23.6) | 78(24.9) | |
| 3rd Quartile | 640(25.1) | 560(25.0) | 80(25.6) | |
| Highest Quartile | 681(26.7) | 607(27.1) | 74(23.6) | |
| % of Family living below poverty line | ||||
| Lowest Quartile | 629(24.6) | 548(24.5) | 81(25.9) | 0.5019 |
| 2nd Quartile | 627(24.6) | 561(25.0) | 66(21.1) | |
| 3rd Quartile | 641(25.1) | 560(25.0) | 81(25.9) | |
| Highest Quartile | 656(25.7) | 571(25.5) | 85(27.2) | |
| Pre-CHF*** | ||||
| No | 2048(80.2) | 1798(80.27) | 250(79.87) | 0.8693 |
| Yes | 505(19.8) | 442(19.73) | 63(20.13) | |
| Pre-Other Heart Disease*** | ||||
| No | 2038(79.8) | 1786(79.73) | 252(80.51) | 0.7477 |
| Yes | 515(20.2) | 454(20.27) | 61(19.49) | |
| Pre-Hypertension*** | ||||
| No | 1313(51.4) | 1161(51.83) | 152(48.56) | 0.2785 |
| Yes | 1240(48.6) | 1079(48.17) | 161(51.44) | |
| Pre-Diabetes*** | ||||
| No | 2100(82.3) | 1845(82.37) | 255(81.47) | 0.6974 |
| Yes | 453(17.7) | 395(17.63) | 58(18.53) | |
| Pre-Respiratory Dz *** | ||||
| No | 2031(79.6) | 1780(79.46) | 251(80.19) | 0.765 |
| Yes | 522(20.5) | 460(20.54) | 62(19.81) | |
| Number of Fractions | ||||
| Mean ± SD | 24±8.5 | 24±8.5 | 25±8.1 | 0.1433 |
| Median | 26 | 26 | 28 |
*
All TCR Patients Marital Status were Unknown
**
The six SEER regions include: Conneticut, Detroit, Iowa, New Mexico, Seattle, Utah
***
Pre-disease within one-year before Esophageal Cancer Diagnosis, parts of Comorbidity disease, therefore not included into Cox Modeling that has adjusted for Charlson Score.