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. 2018 Jul 4;7:57. Originally published 2018 Jan 16. [Version 2] doi: 10.12688/f1000research.13612.2

Figure 6. Structural comparison of BCD090-M2 crystallized in different space groups.

Figure 6.

A) the three structures, 6EZW, 6F0D chain A, and 6F0D chain B, were superimposed, the structural alignment was based on C α atoms of framework regions. CDRs H1 and H3 showed little structural variation, while CDR H2 adopted different conformations in 6EZW and 6F0D, which are shown in blue and green color. B) Electron density map (F-obs, Phi-model, 1.0 σ) for CDR H2 (residues 51-67) of 6EZW. The quality of electron density maps allowed us to unambiguously trace the loop and place amino-acid side chains.