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. 2018 Mar 27;43(10):2093–2100. doi: 10.1038/s41386-018-0048-2

Fig. 4.

Fig. 4

DA neuron activation in VTA selectively requires cholinergic inputs to vSub, whereas DA neuron inhibition in SNc selectively requires GABAergic inputs to vSub. (a) Scopolamine (Scop; 8 µg in 1.0 µL, N = 6 rats per group), but not bicuculline (Bicuc; 12.5 ng in 0.5 µL), infusion into the vSub selectively prevented MS activation-induced increases in the number of active DA neurons in VTA (*Tukey’s P < 0.05). (b) Bicuculline, but not scopolamine, infusion (N = 6 rats per group) into the vSub selectively prevented MS activation-induced decreases in the number of active DA neurons in SNc (*Tukey’s P < 0.05).