Table 3.

Impact of hybrids 4m and 7b on the expression levels of Bcl-2 and Bax and on the active caspase-3 level in MDA-MB-231 cancer cells treated with each hybrid at its IC₅₀ concentration.

Compound	Bax (pg/mg of Total Protein)	Bcl-2 (ng/mg of Total Protein)	Bax/Bcl-2	Caspase-3 (ng/mg of Total Protein)
4m	274.8 ± 13.5 (11.1) *	2.1 ± 0.1 (0.33) *	130.5	0.19 ± 0.01 (6.4) *
7b	180.0 ± 7.3 (7.3) *	2.8 ± 0.1 (0.45) *	64.1	0.15 ± 0.01 (4.9) *
Control	24.7 ± 1.7	6.3 ± 0.2	3.9	0.03 ± 0.01

* Numbers given between parentheses are the numbers of folds of control.