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. 2018 Jul 10;23(7):1674. doi: 10.3390/molecules23071674

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cryptococcus neoformans infection in the mice treated with prosopilosidine administered bid. Graph showing live colony forming units (CFU) of C. neoformans per gram of brain tissue and percent reduction in infection by prosopilosidine treatment given at doses 0.06215 and 0.125 mg/kg body weight and amphotericin B (1.5 mg/kg body weight), as compared to the vehicle control. Amp B: Amphotericin B (1.5 mg/kg body weight). Data are shown as mean + SEM (n = 5) and was analyzed with ANOVA. *** p < 0.001 was considered statistically significant compared to the vehicle control.