. 2018 Jun 27;23(7):1548. doi: 10.3390/molecules23071548

Table 1.

Analytical concentration parameters of the calibration equations for the determination of metformin and rosuvastatin in human plasma by HILIC-ESI/MS.

Compound	Concentration Range, ng mL⁻¹	Regression Equations ^a	r ^b	Standard Deviation		S_r ^c
Compound	Concentration Range, ng mL⁻¹	Regression Equations ^a	r ^b	Slope	Intercept	S_r ^c
Mean of three calibration curves over a period of one month
Metformin	62.5–5000	R_Mtf = 0.00715 × C_Mtf + 0.066	≥0.996	2.2 × 10⁻⁴	4.3 × 10⁻⁴	≤0.10
Rosuvastatin	2–100	R_Rsv = 0.01775 × C_Rsv − 0.0129	≥0.998	5.2 × 10⁻⁴	7.2 × 10⁻³	≤0.062

^a Ratios of the peak areas signals of metformin, R_Mtf and rosuvastatin, R_Rsv, to that to the internal standard vs. the corresponding concentration of metformin, C_Mtf and rosuvastatin, C_Rsv; ^b Correlation coefficient; ^c Standard error of the estimate.