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Steric and electrostatic contour maps representing the CoMFA model for cytotoxic activity on L6 rat skeletal myoblasts. Compounds shown are the strongest (A; 3) and weakest (B; 16) cytotoxins in the series. Green and white regions, respectively, indicate areas where steric interactions increase and decrease activity. Blue and red regions denote enhancing and detrimental electrostatic effects with the positively charged probe, respectively.
