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. 2018 May 14;37(34):4692–4710. doi: 10.1038/s41388-018-0273-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — KMT2C is the most frequently mutated H3K4 histone methyltransferase in breast cancer. a Mutation frequencies of H3K4 histone methyltransferases in breast cancer tissue samples from the TCGA data set [10] (n = 818). b Percentage of cases with gene mutations detected in the MSKCC-IMPACT metastatic breast cancer patient cohort [60] (n = 746). c Diagram of KMT2C domains with the locations of the identified TCGA mutations. y-axis corresponds to the number of cases with indicated mutation (n = 818)