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. 2018 Jul 31;159(9):3275–3286. doi: 10.1210/en.2018-00561

Figure 4.

Figure 4.

Glucose and insulin tolerance improved in Ob/Ob rescue mice. Measurements of plasma (a) insulin, (b) amylin, (c) C-peptide, (d) glucagon, (e) GIP, (f) peptide yy, (g) glucagon-like peptide-1 (GLP-1), and (h) resistin from blood taken at terminal necropsy. (i) GTT performed after IP injection of glucose (2 mg/kg lean weight), with calculation of area under the curve (AUC) (right). (j) ITT performed after IP injection of insulin (1 U/kg lean weight) and expressed as percentage change from baseline, with calculation of AUC net area from baseline (right). Data represented as mean ± SD (n = 4 to 5). Significance determined by either two-way (GTT and ITT) or one-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.