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Ob/Ob rescue mice are more metabolically active. At ~12 weeks of age, mice were placed in metabolic chambers for indirect calorimetry. (a) Oxygen consumption, (b) respiratory exchange ratio (RER), (c) energy expenditure, and (d) movement. Data represented as the average per 12 hours and expressed as mean ± SEM (n = 4 to 5). Significance determined by one-way ANOVA. **P < 0.01; ***P < 0.001; ****P < 0.0001.
