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. Author manuscript; available in PMC: 2019 Jul 31.

Published in final edited form as: Circulation. 2018 Jul 31;138(5):513–526. doi: 10.1161/CIRCULATIONAHA.117.031635

Table 2.

Characterization of Heart Failure in BMP9^−/− Mice After Two Weeks of TAC

	WT Sham	WT TAC	BMP9^−/− Sham	BMP9^−/− TAC	Eng NAb BMP9^−/− TAC
Mass
Total body weight (g)	24.5 ± 0.6	22.2 ± 1.4^*	25.2 ± 1.5	21.5 ± 1.2^†	22.8 ± 3^†
LV mass (mg)	83 ± 7	149 ± 9^*	88 ± 8	143 ± 12^†	157 ± 15^†
Lung mass (mg)	143 ± 6	349 ± 111^*	137 ± 8	398 ± 58^†	379 ± 129^†
Tibia length (mm)	17.4 ± 0.1	17.5 ± 0.1	17.4 ± 0.2	17.5 ± 0.2	17.4 ± 0.2
LV/TL (mg/mm)	4.7 ± 0.4	8.5 ± 0.5^*	5.2 ± 0.1	8.2 ± 0.8^†	8.9 ± 0.8^†
Lung/TL (mg/mm)	8.2 ± 0.4	20 ± 6.4^*	7.9 ± 0.4	22.8 ± 3.2^†	21.7 ± 7.5^†
Hemodynamic data
Peak systolic pressure (mmHg)	95 ± 8	125 ± 12^*	89 ± 2	96 ± 18^‡	96 ± 10^‡
End diastolic pressure (mmHg)	4 ± 2	22 ± 2^*	6 ± 3	27 ± 4^†^‡	28 ± 3^†^‡
dP/dT max (mmHg/sec)	8449 ± 370	5463 ± 990^*	8291 ± 645	2973 ± 517^†^‡	3232 ± 178^†^‡
dP/dT min (mmHg/sec)	−8382 ± 577	−5253 ± 347^*	−7623 ± 637	−3156 ± 1020^†^‡	−3523 ± 628^†^‡
Ejection fraction (%)	62 ± 4	41 ± 5^*	58 ± 7	28 ± 6^†^‡	29 ± 5^†^‡
Heart rate (bpm)	508 ± 62	546 ± 57	522 ± 48	562 ± 48	546 ± 68

Means±SD. p<0.05:

^*

vs. WT Sham;

^†

vs. BMP9^−/− Sham;

^‡

vs. WT TAC