Table 1.

Chemotherapy substrates for ATP-binding cassette (ABC) transporters (adapted from [5]).

Name	Exogenous Chemotherapy Substance
MDR1, ABCB1, P-GP	Anthracyclines (doxorubucin, daunorubicin, epirubicin), actinomycin D, colchicine, podophyllotoxin (etoposide, teniposide), methotrexate (only in carrier-deficient cells), mitomycin C, mitoxantrone, taxenes (paclitaxel, docetaxel), vinca alkaloids (vincristine, vinblastine)
MRP1, ABCC1	Anthracyclines, cochicine, etoposide, heavy metals (arsenite, arsenate, antimonials), vincristine, vinblastine, paclitaxel
MRP2, ABCC2, cMOAT	Cisplatin, CPT-11, doxorubicin, etoposide, methotrexate, SN-38, vincristine, vinblastine
MRP3, ABCC3	Cisplatin, doxorubicin, etoposide, methotrexate, teniopside, vincristine
MRP4, ABCC4	Methotrexate, nucleotide analogs, PMEA *
MRP5, ABCC5	Doxorubicin, methotrexate, nucleotide analogs, topotecan
MRP6, ABCC6	Doxorubicin, etoposide, teniposide
MRP8, ABCC11	5′-Fluorouracil, 5′-fluoro-2′-deoxyuridine, 5′-fluoro-5′-deoxyuridine, PMEA*
BCRP, ABCG2, MXR1, ABCP	Anthracyclines, bisantrene, camptothecin, epirubicin, flavopiridol, mitoxantrone, S-38, topotecan

* PMEA: 2′,3′-dideoxycytidine 9′-(2′-hosphonylmethoxynyl)adenine.