Table 1.
Characterization of anti-C/Ann Arbor/1/50 hemagglutinin-esterase (HE) monoclonal antibodies (MAbs) and selection frequencies of escape mutants of the C/Ann Arbor/1/50 virus.
| Antibody Titer | Selection Frequency (−log10) | ||||||
|---|---|---|---|---|---|---|---|
| MAb | Isotype 1 | ELISA (×104) 1 | HI | NT50 1 | CJP1 | CJP3 | CJP5 |
| J9 | IgG1 | 1600 | 128,000 | 160,000 | 6.18 | 6.53 | 6.69 |
| U9 | IgG1 | 200 | 128,000 | 200 | 5.87 | 5.30 | 6.10 |
| Q5 | IgG2a | 1600 | 64,000 | 16,000 | 5.82 | 6.37 | 6.13 |
| J14 | IgG1 | 1000 | 256,000 | 8,000,000 | 7.16 | 6.28 | 6.97 |
| K16 | IgG1 | 640 | 80 | 320,000 | 5.58 | 4.62 | 5.05 |
| U1 | IgG1 | 200 | 16,000 | 20,000 | 6.96 | 7.58 | 6.36 |
| U2 | IgG1 | 100 | 6400 | 4000 | 5.92 | 5.80 | 5.94 |
| D37 | IgG2a | 200 | 160 | 8000 | ― 2 | ― | ― |
1 Data are from our previous report [17]. 2 ―: not obtained.