Table 2.
Effects of paeoniflorin on the serum biochemical indicators in fructose-fed rats.
| Control | Fructose | Pioglitazone | PF-10 | PF-20 | PF-40 | |
|---|---|---|---|---|---|---|
| TG (mmol/L) | 0.87 ± 0.05 | 1.14 ± 0.10 # | 0.80 ± 0.06 ** | 0.96 ± 0.09 | 0.85 ± 0.08 ** | 0.71 ± 0.09 ** |
| TC (mmol/L) | 1.92 ± 0.10 | 2.37 ± 0.08 ## | 2.05 ± 0.05 * | 2.16 ± 0.12 | 2.05 ± 0.06 * | 1.97 ± 0.07 ** |
| HDL-C (mmol/L) | 0.63 ± 0.06 | 0.76 ± 0.05 # | 0.57 ± 0.03 * | 0.69 ± 0.07 | 0.60 ± 0.05 * | 0.62 ± 0.04 * |
| LDL-C (mmol/L) | 0.95 ± 0.07 | 1.59 ± 0.10 ### | 1.20 ± 0.05 ** | 1.37 ± 0.09 * | 1.23 ± 0.04 ** | 1.18 ± 0.08 ** |
| NEFA (mmol/L) | 0.92 ± 0.11 | 1.53 ± 0.07 ### | 0.88 ± 0.07 *** | 1.15 ± 0.08 ** | 1.07 ± 0.07 *** | 0.92 ± 0.05 *** |
| Insulin (mIU/L) | 11.7 ± 0.5 | 18.3 ± 0.5 ### | 12.6 ± 0.8 *** | 15.9 ± 0.3 * | 14.1 ± 0.9 ** | 14.5 ± 0.9 ** |
| Glucagon (pg/mL) | 194.0 ± 4.6 | 245.6 ± 8.6 ### | 227.7 ± 7.0 * | 235.4 ± 10.8 | 206.8 ± 9.4 ** | 188.7 ± 9.5 *** |
| Glucose (mmol/L) | 5.27 ± 0.09 | 5.43 ± 0.13 | 5.11 ± 0.16 | 5.19 ± 0.16 | 5.08 ± 0.13 | 4.98 ± 0.25 |
| ALB (g/L) | 37.9 ± 2.9 | 37.2 ± 1.4 | 37.4 ± 3.5 | 37.4 ± 4.3 | 38.9 ± 2.9 | 38.5 ± 1.9 |
| AST (IU/L) | 17.1 ± 0.7 | 18.8 ± 0.4 | 16.9 ± 0.6 | 15.3 ± 0.8 * | 12.8 ± 0.5 ** | 12.2 ± 0.9 ** |
| ALT (IU/L) | 7.70 ± 1.34 | 8.23 ± 0.75 | 9.42 ± 1.54 | 9.34 ± 0.82 | 8.23 ± 1.15 | 8.84 ± 0.95 |
Data are expressed as the mean ± SEM. (n = 8). Data are analyzed by one-way ANOVA followed by Dunnett’s post hoc test. # p < 0.05, ## p < 0.01 and ### p < 0.001 vs. control group. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. fructose group. PF-10: 10 mg/kg of paeoniflorin; PF-20: 20 mg/kg of paeoniflorin; PF-40: 40 mg/kg of paeoniflorin. TG: Triglyceride; TC: Total cholesterol; HDL-C: High density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; NEFA: Non-esterified fatty acid; ALB: Albumin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.