Fig. 1.

FLYCOP diagram. Follow the arrows from input (top left corner) to output (top right corner) in a counter-clockwise direction. In this exemplifying consortium optimization by FLYCOP, in each puzzle, the three colored big pieces (green, blue and red) represents three different microbial strains in the consortium. The different brown and gray little squares represent two distinct metabolites whose secretion rate should be optimized and distributed among the consortium members. Thus, in the putative input configurations there are different metabolite secretion rates and distributions, and the output puzzle represents the best consortium configuration found by FLYCOP, maximizing the secretion