South African guideline for the management of community-acquired pneumonia in adults
In the article that appeared on Page 1469-1502 of the Vol 9, No 6 (June 2017) Issue of the Journal of Thoracic Disease (1), there is an error in Table 2: the dose of Clarithromycin 1 g XL should be 1 g XL daily, not 1g XL 12 hourly.
Therefore, the correct table is as follows (Table 2):
Table 2. Dose and route of administration for antibiotics prescribed for CAP.
| Antibiotics | Route | Dose | Time of administration |
|---|---|---|---|
| Penicillins | |||
| Benzylpenicillin (S. pneumoniae MIC ≤0.5 mg/L) | IV | 2 MU | 6 hourly |
| Benzylpenicillin (S. pneumoniae MIC ≤1 mg/L) | IV | 4 MU | 6 hourly |
| Benzylpenicillin (S. pneumoniae MIC ≤2 mg/L) | IV | 4 MU | 4 hourly |
| Amoxicillin | PO | 1 g | 8 hourly |
| Amoxicillin-clavulanate | PO | 1 g | 8 hourly |
| PO | 2 g SR | 12 hourly | |
| IVI | 1.2 g | 8 hourly | |
| Amoxicillin-clavulanate/plus amoxicillin | PO | 375 mg/plus 500 mg | 8 hourly/8 hourly |
| Ampicillin | IVI | 1–2 g | 6 hourly |
| Cephalosporins | |||
| Cefuroxime axetil | PO | 750 mg | 8 hourly |
| Cefuroxime | IVI | 1.5 g | 8 hourly |
| Cefpodoxime | PO | 400 mg | 12 hourly |
| Ceftriaxone | IVI | 1–2 g | 24 hourly |
| Cefotaxime | IVI | 1–2 g | 8 hourly |
| Ceftaroline | IVI | 600 mg | 12 hourly |
| Fluoroquinolones | |||
| Moxifloxacin | PO | 400 mg | Daily |
| IVI | 400 mg | Daily | |
| Levoflloxacin | PO | 750 mg/500 mg | Daily/12 hourly |
| IVI | 750 mg/500 mg | Daily/12 hourly | |
| Macrolides/azalide | |||
| Erythromycin | PO | 500 mg | 6 hourly |
| IVI | 1 g | 6 hourly | |
| Clarithromycin | PO | 500 mg | 12 hourly |
| PO | 1 g XL | Daily | |
| IVI | 500 mg | 12 hourly | |
| Azithromycin | PO | 500 mg | Daily |
| IVI | 500 mg | Daily | |
| Tetracyclines | |||
| Doxycycline | PO | 200 mg/100 mg | Stat (200 mg) followed by 100 mg 12 hourly |
| Carbapenems | |||
| Ertapenem | IVI/IM | 1 g | Daily |
CAP, community acquired pneumonia.
We are sorry for the inconvenience caused.
References
- 1.Boyles TH, Brink A, Calligaro GL, et al. South African guideline for the management of community-acquired pneumonia in adults. J Thorac Dis 2017;9:1469-502. 10.21037/jtd.2017.05.31 [DOI] [PMC free article] [PubMed] [Google Scholar]
