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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Nature. 2018 Aug 15;560(7719):447–452. doi: 10.1038/s41586-018-0420-8

Extended Data Fig. 1. Ligand-gated signaling of A. bakeri and An. gambiae Orcos.

Extended Data Fig. 1

a, Fluorescence changes in HEK293 cells transfected with a genetically encoded Ca2+ indicator, GCaMP6s, and Orco from A. bakeri (Abak; closed circles) or An. gambiae (Agam; open circles) alone, or with an An. gambiae OR. Dose-response curves were obtained by titrating with VUAA1 or the cognate odour of the OR. b, Average fitted Hill equation parameters from N number of independent replicates. EC50 is the concentration for half-maximal response and n is the Hill coefficient (both mean ± s.d.). 245-T is 2,4,5-trimethylthiazole.