Abstract
Background
Primary care databases represent a rich source of data for health care research; however, the quality of recording of secondary care events in these databases is uncertain. This study sought to investigate the completeness of recording of hospital admissions for bleeds in primary care records and explore the impact of incomplete recording on estimates of bleeding risk associated with antithrombotic treatment.
Methods
The study population consisted of adults with non-valvular atrial fibrillation who had at least one bleed recorded in either the Clinical Practice Research Datalink (CPRD) or Hospital Episode Statistics (HES) while receiving prescriptions for an oral anticoagulant. The proportion of bleeds recorded in HES that had a corresponding bleed recorded in the subsequent 12 weeks in CPRD was calculated, and factors associated with having a corresponding record were identified. Cox proportional hazards analyses investigating the hazard of subsequent bleeding associated with antithrombotic treatment were carried out using linked CPRD-HES data and using CPRD only data, and the results were compared.
Results
Less than 20% of the 14,361 bleeds recorded in the HES data had a corresponding bleed coded in the CPRD in the subsequent 12 weeks. This proportion varied by bleed characteristics, calendar time, day of week of admission (weekday vs weekend) and oral anticoagulant treatment at the time of the bleed. The hazard of subsequent bleeding associated with vitamin K antagonists (VKAs) and antiplatelet agents (APAs) relative to no antithrombotic treatment were similar using the linked primary and secondary care dataset (VKA HRadj 1.06 CI95 0.96–1.16; APA HRadj 1.08 CI95 0.96–1.21) and the unlinked primary care data (VKA HRadj 1.12 CI95 1.01–1.24; APA HRadj 1.06 CI95 0.95–1.20).
Conclusion
Secondary care bleeding events are not completely recorded in primary care records and under-recording may be differential with respect to a variety of factors, including antithrombotic treatment. While the impact of under-recording on estimates of the comparative safety of antithrombotic drugs was limited, the extent of the under-recording suggests its potential impact should be considered, and ideally evaluated in future studies utilizing standalone primary care data.
Keywords: real-world data, data linkage, comparative effectiveness, secondary care, atrial fibrillation
Background
Within the UK National Health Service (NHS), services which typically act as the first point of contact with the health care system are referred to as “primary care” and include general practitioners (GPs), dentists, pharmacists and optometrists. Within the NHS, the GP also plays the role of gatekeeper, managing referral to most non-emergency secondary (hospital and community) and tertiary (highly specialized) health care services. As a result, the majority of the UK population are registered with a GP and the GP record is the patient’s primary medical record.1 In line with this, guidelines indicate that the details of secondary care encounters should be routinely communicated to an individual’s GP practice in order to allow for these details to be recorded and ensure continuity of care.2 Databases containing data collected in UK primary care have therefore been widely used as a stand-alone resource for research into medical conditions and the drugs used to treat them.3
More recently, the linkage of English secondary and primary care datasets has facilitated the conduct of studies exploring the extent to which secondary care events are coded in primary care records. A number of these studies have found coding to be suboptimal, with 17% of cancers, 34% of GI bleeds, 21% of myocardial infarctions, 22% of poisoning events and 9% of fractures recorded in the linked dataset not appearing in the primary care record.4–7 These results suggest the use of primary care records as a standalone source for research into these conditions is unsuitable and may generate bias.
In order to explore the potential for UK primary care databases to generate real world evidence (RWE) on the safety and effectiveness of antithrombotic treatment, this study investigated the extent to which secondary care bleeds are coded in primary care records among a cohort of individuals with non-valvular atrial fibrillation (NVAF). The study also sought to understand the impact of incomplete recording on estimates of bleeding risk associated with antithrombotic treatment.
Methods
Data source
The study was carried out using a linked Clinical Practice Research Datalink (CPRD) – Hospital Episode Statistics (HES) dataset. This dataset combines anonymized medical-record data for patients registered with participating GPs in England (the CPRD dataset) with details of their admissions to NHS hospitals (the HES dataset). The linked dataset therefore includes longitudinal information on diagnoses, symptoms, laboratory tests and prescriptions issued by the GP in addition to information on referrals to specialists, hospital admission diagnoses, hospital procedures and deaths.8 Clinical events in the CPRD are recorded using the “Read code” clinical coding system. Hospital discharge diagnoses in HES are recorded using the international classification of disease (ICD)–10 clinical coding system. Greater than 98% of the UK population are registered with a GP and individuals registered with a GP must opt out of data collection in order to be excluded from the CPRD dataset. Despite over-representing certain geographical areas of the UK, the CPRD has been found to be representative of the UK population with regard to sex, age and ethnicity.8 HES captures information on all NHS hospital admissions occurring in England and on admissions to independent sector providers if funded by the NHS (est. 98–99% of hospital activity).9
Recording of secondary care bleeds in primary care data
The study population consisted of all adults with a diagnosis of atrial fibrillation recorded in the CPRD or HES who had at least one clinically relevant bleed recorded in either data source between first January 2003 and 31 January 2016 while receiving prescriptions for oral anticoagulant (OAC) treatment. Individuals with codes indicating their atrial fibrillation was valvular were excluded as despite sharing the same electrophysiological abnormality, the differing etiology of this valvular atrial fibrillation warrants the separate consideration of such individuals. Code lists defining atrial fibrillation, valvular conditions and clinically relevant bleeds are provided in the data supplement (Tables 1–6).
Table 1.
ICD codes used to identify individuals with atrial fibrillation
| ICD10_code | Diagnosis |
|---|---|
| I48 | Atrial fibrillation and flutter |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.2 | Chronic atrial fibrillation |
| I48.3 | Typical atrial flutter |
| I48.4 | Atypical atrial flutter |
| I48.9 | Atrial fibrillation and atrial flutter, unspecified |
Table 2.
ICD codes used to identify and exclude individuals whose atrial fibrillation was valvular in nature
| ICD10_code | Diagnosis |
|---|---|
| I05 | Rheumatic mitral valve diseases |
| I05.0 | Rheumatic mitral stenosis |
| I05.2 | Rheumatic mitral stenosis with insufficiency |
| I05.8 | Other rheumatic mitral valve diseases |
| I05.9 | Rheumatic mitral valve disease, unspecified |
| I08 | Multiple valve diseases |
| I08.0 | Disorders of both mitral and aortic valves |
| I08.1 | Disorders of both mitral and tricuspid valves |
| I08.3 | Combined disorders of mitral, aortic and tricuspid valves |
| I08.8 | Other multiple valve diseases |
| I08.9 | Multiple valve disease, unspecified |
| T82.0 | Mechanical complication of heart valve prosthesis |
| T82.6 | Infection and inflammatory reaction due to cardiacvalve prosthesis |
| T82.8 | Other specified complications of cardiac and vascular prosthetic devices, implants and grafts |
| T82.9 | Unspecified complication of cardiac and vascular prosthetic device, implant and graft |
| Z95.2 | Presence of prosthetic heart valve |
| Z95.4 | Presence of other heart-valve replacement |
Table 3.
Read codes used to identify individuals with atrial fibrillation
| Read code | Read term |
|---|---|
| 14AN.00 | H/O: atrial fibrillation |
| 14AR.00 | History of atrial flutter |
| 3272.00 | ECG: atrial fibrillation |
| 3273.00 | ECG: atrial flutter |
| 662S.00 | Atrial fibrillation monitoring |
| 6A9..00 | Atrial fibrillation annual review |
| 7,936A00 | Implant intravenous pacemaker for atrial fibrillation |
| 793M100 | Percutaneous transluminal ablation of atrial wall for atrial flutter |
| 793M200 | Percutaneous transluminal internal cardioversion NEC |
| 793M300 | Percutaneous transluminal ablation of conducting system of heart for atrial flutter NEC |
| 8CMW200 | Atrial fibrillation care pathway |
| 8HTy.00 | Referral to atrial fibrillation clinic |
| 8OAD.00 | Provision of written information about atrial fibrillation |
| 9hF..00 | Exception reporting: atrial fibrillation quality indicators |
| 9hF1.00 | Excepted from atrial fibrillation quality indicators: informed dissent |
| 9Os..00 | Atrial fibrillation monitoring administration |
| 9Os0.00 | Atrial fibrillation monitoring first letter |
| 9Os1.00 | Atrial fibrillation monitoring second letter |
| 9Os2.00 | Atrial fibrillation monitoring third letter |
| 9Os3.00 | Atrial fibrillation monitoring verbal invite |
| 9Os4.00 | Atrial fibrillation monitoring telephone invite |
| G573.00 | Atrial fibrillation and flutter |
| G573000 | Atrial fibrillation |
| G573100 | Atrial flutter |
| G573200 | Paroxysmal atrial fibrillation |
| G573300 | Non-rheumatic atrial fibrillation |
| G573400 | Permanent atrial fibrillation |
| G573500 | Persistent atrial fibrillation |
| G573600 | Paroxysmal atrial flutter |
| G573z00 | Atrial fibrillation and flutter NOS |
Abbreviations: ECG, electrocardiogram; NEC, not elsewhere classified; H/O, history of; NOS, not otherwise specified.
Table 4.
Read codes used to identify and exclude individuals whose atrial fibrillation was valvular in nature
| Read code | Read term |
|---|---|
| 7910200 | Prosthetic replacement of mitral valve |
| 7910211 | Bjork–Shiley prosthetic replacement of mitral valve |
| 7910212 | Bjork–Shiley prosthetic replacement of mitral valve |
| 7910213 | Carpentier prosthetic replacement of mitral valve |
| 7910214 | Edwards prosthetic replacement of mitral valve |
| 7910300 | Replacement of mitral valve NEC |
| 7910400 | Mitral valvuloplasty NEC |
| 7911200 | Prosthetic replacement of aortic valve |
| 7911300 | Replacement of aortic valve NEC |
| 7911500 | Transapical aortic valve implantation |
| 7911600 | Transluminal aortic valve implantation |
| 7914200 | Prosthetic replacement of valve of heart NEC |
| 7914211 | Edwards prosthetic replacement of valve of heart |
| 7914212 | Starr prosthetic replacement of valve of heart |
| 7914300 | Replacement of valve of heart NEC |
| 7914600 | Replacement of truncal valve |
| 7915000 | Revision of plastic repair of mitral valve |
| 7916000 | Open mitral valvotomy |
| 7917000 | Closed mitral valvotomy |
| 7919000 | Percutaneous transluminal mitral valvotomy |
| 7910.00 | Plastic repair of mitral valve |
| 7910.11 | Mitral valvuloplasty |
| 7910.12 | Replacement of mitral valve |
| 7910y00 | Other specified plastic repair of mitral valve |
| 7910z00 | Plastic repair of mitral valve NOS |
| 7911.12 | Replacement of aortic valve |
| 7914.11 | Replacement of unspecified valve of heart |
| G11..00 | Mitral valve diseases |
| G110.00 | Mitral stenosis |
| G112.00 | Mitral stenosis with insufficiency |
| G112.12 | Mitral stenosis with incompetence |
| G112.13 | Mitral stenosis with regurgitation |
| G113.00 | Nonrheumatic mitral valve stenosis |
| G11z.00 | Mitral valve disease NOS |
| G13..00 | Diseases of mitral and aortic valves |
| G130.00 | Mitral and aortic stenosis |
| G131.00 | Mitral stenosis and aortic insufficiency |
| G131.13 | Mitral stenosis and aortic incompetence |
| G131.14 | Mitral stenosis and aortic regurgitation |
| G13y.00 | Multiple mitral and aortic valve involvement |
| G13z.00 | Mitral and aortic valve disease NOS |
| G540z00 | Mitral valve disorders NOS |
| G544.00 | Multiple valve diseases |
| G544100 | Disorders of both mitral and tricuspid valves |
| G544200 | Combined disorders of mitral, aortic and tricuspid valves |
| G544X00 | Multiple valve disease, unspecified |
| Gyu1000 | [X]Other mitral valve diseases |
| Gyu5500 | [X]Other nonrheumatic mitral valve disorders |
| Gyu5D00 | [X]Multiple valve disorders/diseases CE |
| P65..00 | Congenital mitral stenosis |
| P650.00 | Congenital mitral stenosis, unspecified |
| P65z.00 | Congenital mitral stenosis NOS |
| SP00200 | Mechanical complication of heart valve prosthesis |
| SyuK611 | [X]Embolism from prosthetic heart valve |
| TB01200 | Implant of heart valve prosthesis + complication, no blame |
| ZV43300 | [V]Has artificial heart valve |
| ZV45H00 | [V]Presence of prosthetic heart valve |
| ZVu6e00 | [X]Presence of other heart valve replacement |
Notes: [V] Supplementary factors influencing health status or contact with health services other than for illness (ICD). [X] Terms which have been added to the Read Codes in order to ensure that every ICD-10 code is cross-mapped to from a Read Code.
Abbreviations: NEC, not elsewhere classified; NOS, not otherwise specified.
Table 5.
ICD codes defining clinically relevant hospital bleeds and their locations
| ICD code | Description | Location |
|---|---|---|
| I85.0 | Esophageal varices with bleeding | GI |
| K25.0 | Gastric ulcer, acute with hemorrhage | GI |
| K25.2 | Gastric ulcer, acute with both hemorrhage and perforation | GI |
| K25.4 | Gastric ulcer, chronic or unspecified with hemorrhage | GI |
| K25.6 | Chronic or unspecified with both hemorrhage and perforation | GI |
| K26.0 | Duodenal ulcer, acute with hemorrhage | GI |
| K26.2 | Duodenal ulcer, acute with both hemorrhage and perforation | GI |
| K26.4 | Duodenal ulcer, chronic or unspecified with hemorrhage | GI |
| K26.6 | Chronic or unspecified with both hemorrhage and perforation | GI |
| K27.0 | Peptic ulcer, acute with hemorrhage | GI |
| K27.2 | Peptic ulcer, acute with both hemorrhage and perforation | GI |
| K27.4 | Peptic ulcer, chronic or unspecified with hemorrhage | GI |
| K27.6 | Chronic or unspecified with both hemorrhage and perforation | GI |
| K28.0 | Gastrojejunal ulcer, acute with hemorrhage | GI |
| K28.2 | Acute with both hemorrhage and perforation | GI |
| K28.4 | Gastrojejunal ulcer, chronic or unspecified with hemorrhage | GI |
| K28.6 | Chronic or unspecified with both hemorrhage and perforation | GI |
| K29.0 | Acute hemorrhagic gastritis | GI |
| K62.5 | Hemorrhage of anus and rectum | GI |
| K92.0 | Hematemesis | GI |
| K92.1 | Melena | GI |
| K92.2 | Gastrointestinal hemorrhage, unspecified | GI |
| I84.1 | Internal hemorrhoids with other complications | GI |
| I84.3 | External thrombosed hemorrhoids | GI |
| I84.4 | External hemorrhoids with other complications | GI |
| I84.8 | Unspecified hemorrhoids with other complications | GI |
| I98.3 | Esophageal varices with bleeding in diseases classified elsewhere | GI |
| K22.6 | Gastro-esophageal laceration-hemorrhage syndrome | GI |
| K31.8 | Angiodysplasia of stomach and duodenum with hemorrhage | GI |
| K55.2 | Angiodysplasia of the colon with bleeding | GI |
| K55.8 | Angiodysplasia of the small intestine with hemorrhage | GI |
| K57.0 | Diverticulosis of the small intestine with perforation, abscess and bleeding | GI |
| K57.1 | Diverticulosis of the small intestine without perforation and abscess, with bleeding | GI |
| K57.2 | Diverticulosis of the colon with perforation, abscess and bleeding | GI |
| K57.3 | Diverticulosis of the colon without perforation or abscess, with bleeding | GI |
| K57.4 | Diverticular disease of both the small intestine and the large intestine with perforation, abscess and bleeding | GI |
| K57.5 | Diverticular disease of both the small intestine and the large intestine without perforation or abscess, with bleeding | GI |
| K57.8 | Diverticular disease of intestine, part unspecified, with perforation, abscess and bleeding | GI |
| K57.9 | Diverticular disease of intestine, part unspecified, without perforation or abscess, with bleeding | GI |
| I60 | Subarachnoid hemorrhage | IC |
| I60.0 | Subarachnoid hemorrhage from carotid siphon and bifurcation | IC |
| I60.1 | Subarachnoid hemorrhage from middle cerebral artery | IC |
| I60.2 | Subarachnoid hemorrhage from anterior communicating artery | IC |
| I60.3 | Subarachnoid hemorrhage from posterior communicating artery | IC |
| I60.4 | Subarachnoid hemorrhage from basilar artery | IC |
| I60.5 | Subarachnoid hemorrhage from vertebral artery | IC |
| I60.6 | Subarachnoid hemorrhage from other intracranial arteries | IC |
| I60.7 | Subarachnoid hemorrhage from intracranial artery, unspecified | IC |
| I60.8 | Other subarachnoid hemorrhage | IC |
| I60.9 | Subarachnoid hemorrhage, unspecified | IC |
| I61 | Intracerebral hemorrhage | IC |
| I61.0 | Intracerebral hemorrhage in hemisphere, subcortical | IC |
| I61.1 | Intracerebral hemorrhage in hemisphere, cortical | IC |
| I61.2 | Intracerebral hemorrhage in hemisphere, unspecified | IC |
| I61.3 | Intracerebral hemorrhage in brain stem | IC |
| I61.4 | Intracerebral hemorrhage in cerebellum | IC |
| I61.5 | Intracerebral hemorrhage, intraventricular | IC |
| I61.6 | Intracerebral hemorrhage, multiple localized | IC |
| I61.8 | Other intracerebral hemorrhage | IC |
| I61.9 | Intracerebral hemorrhage, unspecified | IC |
| I62 | Other nontraumatic intracranial hemorrhage | IC |
| I62.0 | Subdural hemorrhage (acute) (nontraumatic) | IC |
| I62.1 | Nontraumatic extradural hemorrhage | IC |
| I62.9 | Intracranial hemorrhage (nontraumatic), unspecified | IC |
| I69.0 | Sequelae of subarachnoid hemorrhage | IC |
| I69.1 | Sequelae of intracerebral hemorrhage | IC |
| I69.2 | Sequelae of other nontraumatic intracranial hemorrhage | IC |
| S06.5 | Traumatic subdural hemorrhage | IC |
| S06.6 | Traumatic subarachnoid hemorrhage | IC |
| S06.4 | Epidural hemorrhage | IS |
| G95.1 | Vascular myelopathies (including hematomyelia) | IS |
| H21.0 | Hyphema | IO |
| H31.41 | Hemorrhagic choroidal detachment | IO |
| H35.73 | Hemorrhagic detachment of retinal pigment epithelium | IO |
| H44.81 | Hemophthalmos | IO |
| H47.02 | Hemorrhage in optic nerve sheath | IO |
| H31.3 | Choroidal hemorrhage and rupture | IO |
| H35.6 | Retinal hemorrhage | IO |
| H43.1 | Vitreous hemorrhage | IO |
| H45.0 | Vitreous hemorrhage in diseases classified elsewhere | IO |
| N42.1 | Congestion and hemorrhage of prostate | U |
| N02 | Recurrent and persistent hematuria | U |
| N02.6 | Recurrent and persistent hematuria, dense deposit disease | U |
| N02.8 | Recurrent and persistent hematuria, other | U |
| N02.9 | Recurrent and persistent hematuria, unspecified | U |
| R31 | Unspecified hematuria | U |
| R31.0 | Gross hematuria | U |
| R31.9 | Hematuria, unspecified | U |
| M25.0 | Hemarthrosis | IA |
| R04 | Hemorrhage from respiratory passages | R |
| R04.1 | Hemorrhage from throat | R |
| J94.2 | Hemothorax | R |
| R04.0 | Epistaxis | R |
| R04.2 | Hemoptysis | R |
| R04.8 | Hemorrhage from other sites in respiratory passages | R |
| R04.9 | Hemorrhage from respiratory passages, unspecified | R |
| I23.0 | Hemopericardium as current complication following acute myocardial infarction | PC |
| I31.2 | Hemopericardium, not elsewhere classified | PC |
| S26.0 | Injury of heart with hemopericardium | PC |
| N83.6 | Hematosalpinx | GYN |
| N85.7 | Hematometra | GYN |
| N89.7 | Hematocolpos | GYN |
| N92.1 | Excessive and frequent menstruation with irregular cycle | GYN |
| N93 | Other abnormal uterine and vaginal bleeding | GYN |
| N93.8 | Other specified abnormal uterine and vaginal bleeding | GYN |
| N93.9 | Abnormal uterine and vaginal bleeding, unspecified | GYN |
| N95.0 | Postmenopausal bleeding | GYN |
| D69 | Purpura and other hemorrhagic conditions | CUT |
| I71.3 | Abdominal aortic aneurysm, ruptured | RP |
| I71.5 | Thoracoabdominal aortic aneurysm, ruptured | RP |
| K66.1 | Hemoperitoneum | RP |
| H11.3 | Conjunctival hemorrhage | OTH |
| R31.1 | Benign essential microscopic hematuria | OTH |
| H92.2 | Otorrhagia | OTH |
| I71.1 | Thoracic aortic aneurysm, ruptured | OTH |
| I71.8 | Aortic aneurysm of unspecified site, ruptured | OTH |
| E07.8 | Other specified disorders of thyroid (including hemorrhage of thyroid) | OTH |
| E27.4 | Other and unspecified adrenocortical insufficiency (including adrenal hemorrhage) | OTH |
| M62.2 | Ischemic infarction of muscle (compartment syndrome, non-traumatic) | COMP |
| T79.6 | Traumatic ischemia of muscle (compartment syndrome) | COMP |
Abbreviations: IC, intracranial bleed; GI, gastrointestinal bleed; IS, intraspinal bleed; IO, intraocular bleed; PC, pericardial bleed; U, urinary bleed; IA, intraarticular bleed; R, respiratory; GYN, gynecological bleed; COMP, compartment syndrome; CUT, cutaneous/subcutaneous hemorrhage; RP, retroperitoneal bleed; OTH, other bleed.
Table 6.
Read codes identifying bleeds in the CPRD
| Readcode | Description | Location |
|---|---|---|
| 158..12 | Vaginal bleeding | GYN |
| 16R..00 | Bleeding symptom | OTH |
| 1928.00 | Bleeding gums | GUM |
| 196B.00 | Painful rectal bleeding | GI |
| 196C.00 | Painless rectal bleeding | GI |
| 1C6..00 | Nose bleed symptom | R |
| 1C62.00 | Has nose bleeds - epistaxis | R |
| 1C6Z.00 | Nose bleed symptom NOS | R |
| 2BB5.00 | O/E - retinal haemorrhages | IO |
| 2BB8.00 | O/E - vitreous haemorrhages | IO |
| 7017000.00 | Evacuation of subdural haematoma | IC |
| 7404.00 | Surgical arrest of bleeding from internal nose | R |
| F42y.11 | Haemorrhage - retinal | IO |
| F42y400 | Subretinal haemorrhage | IO |
| F42y500 | Retinal haemorrhage NOS | IO |
| F444000 | Hyphaema | IO |
| F4K2800 | Vitreous haemorrhage | IO |
| G60..00 | Subarachnoid haemorrhage | IC |
| G61..00 | Intracerebral haemorrhage | IC |
| G61..11 | CVA - cerebrovascular accid due to intracerebral haemorrhage | IC |
| G61..12 | Stroke due to intracerebral haemorrhage | IC |
| G610.00 | Cortical haemorrhage | IC |
| G612.00 | Basal nucleus haemorrhage | IC |
| G613.00 | Cerebellar haemorrhage | IC |
| G617.00 | Intracerebral haemorrhage, intraventricular | IC |
| G61X000 | Left sided intracerebral haemorrhage, unspecified | IC |
| G61X100 | Right sided intracerebral haemorrhage, unspecified | IC |
| G61z.00 | Intracerebral haemorrhage NOS | IC |
| G62..00 | Other and unspecified intracranial haemorrhage | IC |
| G620.00 | Extradural haemorrhage - nontraumatic | IC |
| G621.00 | Subdural haemorrhage - nontraumatic | IC |
| G622.00 | Subdural haematoma - nontraumatic | IC |
| G623.00 | Subdural haemorrhage NOS | IC |
| G62z.00 | Intracranial haemorrhage NOS | IC |
| G850.00 | Oesophageal varices with bleeding | GI |
| G8y0.00 | Haemorrhage NOS | OTH |
| Gyu6200 | [X]Other intracerebral haemorrhage | IC |
| J110100 | Acute gastric ulcer with haemorrhage | GI |
| J110111 | Bleeding acute gastric ulcer | GI |
| J121100 | Chronic duodenal ulcer with haemorrhage | GI |
| J121111 | Bleeding chronic duodenal ulcer | GI |
| J130100 | Acute peptic ulcer with haemorrhage | GI |
| J150000 | Acute haemorrhagic gastritis | GI |
| J510900 | Bleeding diverticulosis | GI |
| J573.00 | Haemorrhage of rectum and anus | GI |
| J573.11 | Bleeding PR | GI |
| J573000 | Rectal haemorrhage | GI |
| J573011 | Rectal bleeding | GI |
| J573012 | PRB - Rectal bleeding | GI |
| J68..00 | Gastrointestinal haemorrhage | GI |
| J681.00 | Melaena | GI |
| J68z.00 | Gastrointestinal haemorrhage unspecified | GI |
| J68z.11 | GIB - Gastrointestinal bleeding | GI |
| J68z000 | Gastric haemorrhage NOS | GI |
| J68z100 | Intestinal haemorrhage NOS | GI |
| J68z200 | Upper gastrointestinal haemorrhage | GI |
| J68zz00 | Gastrointestinal tract haemorrhage NOS | GI |
| K0A2.00 | Recurrent and persistent haematuria | U |
| K197.00 | Haematuria | U |
| K197000 | Painless haematuria | U |
| K197100 | Painful haematuria | U |
| K197300 | Frank haematuria | U |
| K19y400 | Bleeding from urethra | U |
| K19y411 | Urethral bleeding | U |
| K31y000 | Breast haematoma due to nontraumatic cause | OTH |
| K56y111 | Bleeding - vaginal NOS | GYN |
| K56y112 | BPV - Vaginal bleeding | GYN |
| K5E..00 | Other abnormal uterine and vaginal bleeding | GYN |
| K5E2.00 | Abnormal vaginal bleeding, unspecified | GYN |
| N091.00 | Haemarthrosis | IA |
| N091611 | Haemarthrosis of the knee | IA |
| N091M00 | Haemarthrosis of knee | IA |
| N091z00 | Haemarthrosis NOS | IA |
| R047.00 | [D]Epistaxis | R |
| R047.11 | [D]Nosebleed | R |
| R063.00 | [D]Haemoptysis | R |
| R063100 | [D]Pulmonary haemorrhage NOS | R |
| R063z00 | [D]Haemoptysis NOS | R |
| S62..00 | Cerebral haemorrhage following injury | IC |
| S62..11 | Extradural haemorrhage following injury | IC |
| S62..13 | Subdural haemorrhage following injury | IC |
| S622.00 | Closed traumatic subdural haemorrhage | IC |
| S629.00 | Traumatic subdural haematoma | IC |
| S62A.00 | Traumatic extradural haematoma | IC |
| S63..00 | Other cerebral haemorrhage following injury | IC |
| S780500 | Retroperitoneal haematoma | RP |
| SE...11 | Haematoma with intact skin | CUT |
| SE46.00 | Traumatic haematoma | OTH |
| SE4z.11 | Haematoma NOS | OTH |
| SK02.00 | Secondary and recurrent haemorrhage | OTH |
| SK0y.11 | Anterior compartment syndrome | COMP |
| SK0y.12 | Compartment syndrome | COMP |
| SK0y700 | Compartment syndrome | COMP |
| SP21.00 | Peri-operative haemorrhage or haematoma | OTH |
| SP21.12 | Haemorrhage - postoperative | OTH |
Notes: [D] diagnosis. [X] Terms which have been added to the Read Codes in order to ensure that every ICD-10 code is cross-mapped to from a Read Code.
Abbreviations: O/E, on examination; PRB, per-rectal bleeding; PR, per-rectum; NOS, not otherwise specified; BPV, bleeding per vagina; IC, intracranial bleed; GI, gastrointestinal bleed; IS, intraspinal bleed; IO, intraocular bleed; PC, pericardial bleed; U, urinary bleed; IA, intraarticular bleed; R, respiratory; GYN, gynecological bleed; COMP, compartment syndrome; CUT, cutaneous/subcutaneous hemorrhage; RP, retroperitoneal bleed; GUM, gum bleed; OTH, other bleed.
Within this population, all clinically relevant bleeding events recorded in the HES and the CPRD were identified using relevant diagnostic codes and classified according to the location in the body in which they occurred (Tables 5 and 6). We refer to “clinically relevant bleeds” to distinguish these from minor bleeds which are non-clinically consequential; such bleeds are not captured by our data source. The proportion of bleeds recorded in HES that had a corresponding record in the CPRD in the subsequent 12 weeks was calculated, overall and stratified by bleed location.
To identify factors associated with a HES bleed having a corresponding bleeding record coded in the CPRD in the subsequent 12 weeks, generalized estimating equations (GEE) binary regression analysis was performed. The GEE analysis used a binomial distribution, a logit-link and an exchangeable correlation structure to account for the inclusion of repeat bleeds per individual. Bleed characteristics considered in the analysis included OAC treatment at the time of the bleed, bleed type, calendar period, period of week of bleed occurrence (weekday vs weekend). A range of patient characteristics were also considered for inclusion in the model, including age, sex, deprivation (English Index of Multiple Deprivation),10 body mass index (BMI), stroke risk factors (history of stroke/TIA, systemic thromboembolism, congestive heart failure, vascular disease, hypertension, diabetes, CHA2DS2-VASc score), bleeding risk factors (bleeding history, liver disease, renal disease, modified HAS-BLED score) and concomitant medical treatment.
Impact of recording completeness on comparative safety of antithrombotic treatment
In order to further explore the impact under-recording of HES bleeds in primary care data can have on comparative safety and effectiveness analyses, a comparative safety analysis was carried out using two different data sources: a linked CPRD-HES data (linked analysis) and a CPRD only dataset (unlinked analysis). The analysis investigated the impact of using the different data sources on the relative hazard of subsequent bleeding across antithrombotic treatment strategies, within a population of individuals who had suffered a first bleed while using OACs.
For this analysis, the study population consisted of adults with a diagnosis of atrial fibrillation recorded in the CPRD or HES who had a clinically relevant bleed (index bleed) recorded in either data source between 1 January 2003 and 15 March 2012 which occurred while receiving prescriptions for an OAC. Patients were followed from index bleed until the earliest of either 15 March 2012, the date of leaving the database, or the date of death. Prescriptions for vitamin K antagonists (VKAs) or antiplatelet agents (APAs) issued following the first bleed were identified and used to stratify each individuals’ follow-up time into one of three antithrombotic treatment groups: VKA treatment, APA treatment, no antithrombotic treatment. Gaps in treatment of up to 60 days between two prescriptions from the same treatment group were considered to constitute continuous treatment. Cox proportional hazard regression models were used to compare the hazard of subsequent bleeding events across treatment groups in each population, including treatment group as a time varying covariate and controlling for the same patient and bleed characteristics outlined for the GEE analysis above. Hazard ratios are reported along with Wald 95% confidence intervals.
All analyses were carried out in [SAS/STAT] software (SAS Institute Inc., Cary, NC, USA).
Results
A total of 14,361 bleeds recorded in HES were identified among patients with NVAF receiving OAC treatment between 2003 and 2016. The proportion of HES bleeds with a corresponding bleed recorded in the CPRD increased from 12.5% in the first week following the HES bleed to 19.6% after 12 weeks (Table 7). Similar results, stratified by the location of the bleed, are provided in Table 8. A greater proportion of respiratory, intraarticular and intracranial bleeds had a consistent bleed code recorded in the CPRD within 12 weeks (30.1%, 40.7% and 39.2%, respectively) compared to bleeds in other locations, including GI bleeds (13.5%) and intraspinal bleeds (11.6%).
Table 7.
HES bleeds with a corresponding bleed recorded in the CPRD in the subsequent 12 weeks
| Bleeds in HES (n=14,361) | Corresponding bleed recorded in CPRD N (%) | |
|---|---|---|
| Weeks after bleed | ||
| +1 (0–7 days) | 1,799 | (12.5) |
| +2 (0–14 days) | 2,110 | (14.7) |
| +4 (0–28 days) | 2,372 | (16.5) |
| +6 (0–42 days) | 2,543 | (17.7) |
| +8 (0–56 days) | 2,653 | (18.5) |
| +10 (0–70 days) | 2,748 | (19.1) |
| +12 (0–84 days) | 2,822 | (19.6) |
Abbreviations: HES, hospital episode statistics; CPRD, Clinical Practice Research Datalink.
Table 8.
HES bleeds with direct, plausible or possible supporting evidence in the CPRD within 12 weeks, by location of HES bleed
| Bleeds in HES | Corresponding bleed recorded in CPRD N (%) | |
|---|---|---|
| Location | ||
| Total (n=14,361) | 2,822 | (19.6) |
| Intracranial bleed (n=1,713) | 620 | (39.2) |
| GI bleed (n=7,797) | 1,051 | (13.5) |
| Intraspinal bleed (n=43) | 5 | (11.6) |
| Intraocular bleed, major (n=7) | <5 | (NR) |
| Intraocular bleed, not major (n=82) | 13 | (15.8) |
| Pericardial bleed (n<5) | <5 | (NR) |
| Urinary bleed (n=2,296) | 449 | (19.6) |
| Intraarticular bleed (n=162) | 66 | (40.7) |
| Respiratory bleed, major (n<5) | <5 | (NR) |
| Respiratory bleed, not major (n=1,984) | 597 | (30.1) |
| Gynecological bleed (n<5) | <5 | (NR) |
| Compartment syndrome (n=39) | 7 | (17.9) |
| Cutaneous/subcutaneous hemorrhage (n<5) | <5 | (NR) |
| Retroperitoneal bleed (n=84) | <5 | (NR) |
| Intraabdominal retroperitoneal bleed (n=41) | 11 | (26.8) |
| Gum bleed (n<5) | <5 | (NR) |
| Other bleed (n=107) | <5 | (NR) |
Abbreviations: HES, hospital episode statistics; CPRD, Clinical Practice Research Datalink; GI, gastrointestinal; NR, not reported.
Patient characteristics in the linked and unlinked datasets are shown in Table 9. The results of the GEE regression model are provided in Table 10. Of the 14,361 bleeds recorded in HES, intracranial bleeds, bleeds resulting in weekend hospital admission, bleeds occurring longer ago, bleeds occurring during OAC treatment and bleeds occurring in individuals without a history of bleeding risk factors were more likely to have a corresponding bleed recorded in the CPRD in the 12 weeks after hospital admission.
Table 9.
Patient characteristics in the linked and unlinked datasets used in the Cox regression analyses
| Linked CPRD-HES n=7,063 | Unlinked CPRD n=5,197 | |
|---|---|---|
| Age, mean (SD) | 76.7 (9.5) | 76.0 (9.4) |
| Female, % | 45.9 | 42.2 |
| NVAF characteristics | ||
| NVAF duration (from first AF diagnosis to index bleed) | 24.9 (24.2) | 29.1 (24.1) |
| NVAF duration (categorized), % | ||
| <3 months, % | 19.0 | 8.4 |
| 3–6 months, % | 8.4 | 8.0 |
| 6–9 months, % | 7.1 | 7.7 |
| 9–12 months, % | 5.6 | 6.6 |
| ≥12 months, % | 59.8 | 69.3 |
| Newly diagnosed NVAF (past 12 months), % | 40.2 | 30.7 |
| Duration of available baseline period (months), mean (SD) | 465 (213) | 476 (208) |
| Duration of follow-up period in months, mean (SD) | 59.7 (40.7) | 56.0 (35.9) |
| Index bleed characteristics | ||
| Calendar year of index bleed, % | ||
| 2003–2007 | 52.3 | 59.0 |
| 2008–2012 | 47.7 | 41.0 |
| Site of initial bleed, % | ||
| Gastrointestinal | 39.5 | 29.6 |
| Respiratory | 20.2 | 23.6 |
| Urinary | 20.0 | 23.9 |
| Intracranial | 7.4 | 5.0 |
| Intraocular | 1.7 | 2.3 |
| Gynecological | 1.7 | 2.7 |
| Intraarticular | 1.4 | 1.5 |
| Gum | 0.7 | 1.2 |
| Retroperitoneal | 0.5 | 0 |
| All other bleeds | 7.0 | 10.2 |
| Major bleed, % | 17.2 | 8.3 |
| History of bleeding risk factors | ||
| Bleeding history/predisposition, % | 55.1 | 42.2 |
| Liver disease, % | 1.7 | 0.5 |
| Renal disease, % | 23.5 | 25.6 |
| Drugs predisposing to bleedinga, % | 13.2 | 18.1 |
| Modified HAS-BLED score (0–8), mean (SD) | 3.0 (1.1) | 2.6 (1.2) |
| Serum creatinine, mean (SD) | 103.7 (52.1) | 104.9 (51.3) |
| Glomerular filtration rate, mean (SD) | 0.34 (0.4) | 0.34 (0.3) |
| History of stroke risk factors | ||
| Stroke/TIA, % | 24.6 | 20.4 |
| Systemic thromboembolism, % | 1.4 | 0.7 |
| Congestive heart failure, % | 28.2 | 21.8 |
| Vascular diseases, % | 25.2 | 38.2 |
| Hypertension, % | 90.0 | 60.9 |
| Diabetes, % | 16.4 | 15.7 |
| CHAD2 score (0 to 6), mean (SD) | 2.5 (1.3) | 2.0 (1.3) |
| CHA2DS2-VASc score (0–10), mean (SD) | 4.1 (1.6) | 3.7 (1.7) |
| Other medical histories | ||
| Smoking status, % | ||
| Current | 14.3 | 15.2 |
| Past or neverb | 2.5 | 2.9 |
| Unknown | 84.2 | 83.0 |
| BMI, mean (SD) | 27.4 (5.7) | 28.1 (5.8) |
| Underweight, % | 2.2 | 1.6 |
| Normal, % | 30.5 | 20.0 |
| Obese, % | 23.5 | 21.6 |
| Overweight, % | 35.3 | 25.0 |
| Unknown, % | 8.5 | 31.8 |
| Weight, mean (SD) | 78.7 (18.4) | 81.0 (19.4) |
| Active cancer (current/prior 12 months), % | 9.6 | 4.9 |
| Falls, % | 0.1 | 0.2 |
Notes:
Prescriptions within 90 days prior to index bleed.
May overlap with current smoker.
Abbreviations: HAS-BLED, hypertension, abnormal renal and liver function, stroke, bleeding, labile INR, elderly, drugs or alcohol; HES, hospital episode statistics; CPRD, Clinical Practice Research Datalink; AF, atrial fibrillation; NVAF, non-valvular atrial fibrillation; BMI, body mass index; TIA, transient ischemic attack.
Table 10.
Generalized estimating equations (GEE) binary regression analysis investigating factors associated with a HES bleed being recorded in the CPRD
| Variables | OR | 95% CI | |
|---|---|---|---|
| Day of week | Weekday (reference) | 1 | – |
| Weekend | 1.25 | (1.12–1.39) | |
| Calendar period 2003–2005 | 1.43 | (1.19–1.71) | |
| 2006–2008 | 1.31 | (1.12–1.52) | |
| 2009–2011 | 1.09 | (0.93–1.26) | |
| 2012–2016 (reference) | 1 | – | |
| OAC treatment at time of index bleed | No (reference) | 1 | – |
| Yes | 2.26 | (1.58–3.23) | |
| Bleed type | Intracranial major (reference) | 1 | – |
| Extracranial major | 0.39 | (0.32–0.48) | |
| GI CRNMB leading to hospitalization | 0.29 | (0.24–0.35) | |
| GI CRNMB not leading to hospitalization | 0.32 | (0.24–0.43) | |
| Other CRNMB leading to hospitalization | 0.44 | (0.34–0.56) | |
| Other CRNMB not leading to hospitalization | 0.48 | (0.37–0.63) | |
| History of GI ulceration, GI bleeding or intracranial hemorrhage | No (reference) | 1 | – |
| Yes | 0.75 | (0.62–0.91) |
Notes: Time since NVAF diagnosis also adjusted for in the analysis.
Abbreviations: HES, hospital episode statistics; CPRD, Clinical Practice Research Datalink; OAC, oral anticoagulant; GI, gastrointestinal; CRNMB, clinically relevant non-major bleed; NVAF, non-valvular atrial fibrillation.
After applying inclusion and exclusion criteria, 5,197 individuals were identified for inclusion in the Cox regression analyses using CPRD data only (Figure S1) and 7,063 individuals were identified for inclusion in the analysis using CPRD-HES linked data (Figure S2). On average, the population identified using linked CPRD-HES data was slightly older than the population identified using unlinked data only, and contained a greater proportion of females, individuals more recently diagnosed with NVAF, individuals with a history of stroke and bleeding risk factors and individuals with evidence of active cancer (Table 9). The index bleeds identified in the linked population occurred more recently and were more severe than those in the unlinked population, with a greater proportion of gastrointestinal and intracranial bleeds identified (Table 9).
Figure 1 shows the cumulative incidence of bleeding in the unlinked primary care data and the linked primary and secondary care dataset. Adjusting for statistically significant differences in the above characteristics across treatment groups within each population, we found that the hazard of subsequent bleeding associated with VKAs and APAs relative to no antithrombotic treatment were 12% and 6% higher, respectively, when using the unlinked primary care data (VKA HRadj 1.12 CI95 1.01–1.24; APA HRadj 1.06 CI95 0.95–1.20) and were 6% and 8% higher, respectively, when using the linked primary and secondary care dataset (VKA HRadj 1.06 CI95 0.96–1.16; APA HRadj 1.08 CI95 0.96–1.21).
Figure 1.
Cumulative incidence of bleeding in the unlinked primary care data (A) and the linked primary and secondary care dataset (B).
Discussion
This study found that the coding of hospital bleeds in the primary care record was incomplete, with less than 20% of individuals with an inpatient diagnosis for a bleed having a bleed coded in their primary care record in the subsequent 12 weeks. Moreover, differences with respect to key clinical and demographic characteristics were observed between patients identified from primary care vs linked data. While under-recording was found to be differential with regard to a number of factors, including OAC treatment, the incomplete recording of bleeds in primary care was not found to considerably bias estimates of the risk of bleeding associated with antithrombotic treatment.
The low proportion of secondary care bleeds having a corresponding bleed recorded in primary care indicates that as much as 80% of such bleeds could be excluded from a study which utilized primary care data only to identify bleeds. Using primary care data alone will therefore result in false-negative misclassification of exposure, outcome and/or covariate status. The impact of such misclassification is unpredictable and dependent on the study question. While our stratified and GEE analyses suggest that incompleteness varies by a range of factors including OAC treatment, calendar time and bleed location/type, our comparative safety analyses investigating the risk of subsequent bleeding associated with antithrombotic treatment illustrates that for certain study questions the impact on estimates of comparative safety or effectiveness may be small. Despite this, given the extent of under-recording and observed differences in patient characteristics, potential bias introduced through differential misclassification by these and other factors should be taken into consideration in interpreting the results of studies which have used primary care data only to identify bleeds11,12 and in the planning of future studies.
Of GP practices contributing to the CPRD, 57% are eligible for linkage with HES, and no individuals registered with Scottish, Welsh or Northern Irish practices are eligible.13 As a result, the use of a HES linked CPRD dataset can have a considerable impact on the generalizability and sample size available for a given study. Given our observation that the impact of under-recording on relative measures of safety or effectiveness can be limited, the decision to use unlinked CPRD vs HES-linked CPRD data must be made on a study specific basis, based on a comparison of the anticipated value that the HES data can add against the reduction in sample size and generalizability it enforces. Based on the extent of under-recording of secondary care bleeding events in primary care data reported here, and the finding that the HR of subsequent bleeding for VKAs compared to no antithrombotic treatment was slightly higher when using unlinked CPRD data, we suggest that for studies in which bleeding is a key variable, HES linked data is used; at a minimum, to illustrate that findings in the HES-linked data are similar to those in the unlinked data.
Our finding that the odds of a HES bleed having a corresponding CPRD bleed has decreased over time (Table 10) is notable as it suggests that the quality of recording in primary care datasets has decreased over time. This is an interesting finding as it suggests recent efforts to improve and standardize the communication of discharge details between secondary and primary care (eDischarge summaries,2 have yet to make an impact. There is a possibility that the decrease in recording over time may represent a change in recording practices rather than a decrease in the quality of recording, as we used specific Read codes related to a bleed in the CPRD to assess consistency with HES data; however, there may have been other Read codes recorded that suggest a bleed occurred (eg, a code for a medical condition for which bleeding is a common symptom). A previous study investigating recording of upper gastrointestinal bleeds in the CPRD and HES included a range of “probable” and “possible” bleed Read codes and found supporting evidence for a much higher percentage of HES bleeds in the CPRD (66%).5 Further, in clinical practice, some Read codes may have “free text” information recorded against them confirming a bleed occurred. These “free text” data consist of unstandardized text which can be used to elaborate on the information contained in the Read code. Free text data are not currently made available for research purposes; however, they are available to individuals involved in the clinical care of patients. While the information contained in related Read codes and the free text may therefore confirm bleeds in some of the cases we have identified, given the magnitude of uncoded secondary care events it is likely that a clinically relevant proportion of individuals did not have their bleed recorded anywhere in their primary care record. These findings are in line with those of a number of studies that have identified shortcomings in communication during transition of care between secondary and primary care and which have highlighted the safety issues that may result from them.14–21 From a research perspective, the unavailability of free text and non-specificity of the “possible” and “probable” codes included by Crooks et al5 mean that neither represent feasible approaches to identifying bleeding events in stand-alone primary care data and the high proportions of unreported data we report remain relevant.
The observation that the odds of a HES bleed having a corresponding CPRD bleed is higher for bleeds admitted at the weekend is of interest given the publicity surrounding so-called “weekend effects” in the UK, whereby individuals admitted to hospital at the weekend are more likely to have poor outcomes. It may be possible that admission for bleeds at weekends are more likely to be recorded in the CPRD due to their association with poorer outcomes and therefore being more clinically relevant. Previous methodological work exploring the accuracy of HES data for exploring weekend effects has found that events recorded in HES data on weekdays are more likely to be prevalent events inappropriately recorded as incident events and that this may partly explain the better outcomes observed following these events.22 Our finding that HES bleeds admitted on weekdays are less likely to have a corresponding bleed record in the CPRD may therefore reflect the fact that a greater proportion of the weekday admissions are not being recorded by GPs as they are not truly incident bleeds.
Beyond the weekend effect, the potential for inaccurate recording of incident events in HES is an important consideration in interpreting our findings, as thus far we have considered HES to represent a “gold standard” for recording of secondary care events and any events not recorded in the CPRD to represent under-recording in primary care. Inaccuracy in HES coding has been reported previously for a number of event types; however, since the Payment by Results system was introduced in 2004 the average accuracy of coding has been reported to be 96.0% (interquartile range: 89.3–96.2%), P=0.020).23 Notably, this figure has been derived across a range of types of event and most of the studies contributing to this figure focused on the accuracy of ICD coding at the four digit ICD code level. This latter point is important as most of the bleeding ICD codes we have investigated would still have been captured as bleeds had they been miscoded at the four digit level but not at the three digit level. While some of the 80% of secondary care events not coded in the CPRD may therefore not have been true incident bleeds, we believe it is unlikely that a substantial proportion were. An additional limitation of our study is that it explores only the sensitivity of recording in primary care, but does not explore the specificity. In utilizing the CPRD to investigate bleeding events it is important that the potential for false positive classification of bleeds is given consideration.
A further limitation is that our descriptive analyses do not account for extended hospital stays and deaths. That is, 9% of individuals were not discharged from hospital within the 12 weeks following their index bleed. Such individuals may therefore have supporting evidence recorded later, upon discharge from hospital. Removing undischarged individuals from the denominator has a minimal impact on results, increasing the proportion with supporting evidence recorded to 21.5%. Among the 14,361 individuals with an index bleed, 16% died during the 12 week follow-up. While individuals who died during the 12 week follow-up do not have the same opportunity to have supporting evidence recorded, this is still notable from a methodological point of view as a study using primary care data may not capture bleeds presenting in secondary care and resulting in deaths within 12 weeks.
Conclusion
Our results add to the evidence base suggesting secondary care events are not completely recorded in primary care records, and further that under-recording of bleeding events is differential with respect to a variety of factors, including treatment. While the impacts of under-recording on estimates of the comparative safety of antithrombotic drugs obtained from stand-alone primary care data were small, the extent of the under-recording suggests its potential impact should be considered, and ideally evaluated in future studies utilizing stand-alone primary care data.
Supplementary material
Derivation of the study population for the Cox proportional hazards regression analysis using CPRD data only. Percentages shown use the total number of individuals at the next highest level in the flow as their denominator.
Abbreviations: CPRD, Clinical Practice Research Database; HES, hospital episode statistics; OAC, oral anticoagulant; Rx, prescription; Dx, diagnosis.
Derivation of the study population for the Cox proportional hazards regression analysis using linked CPRD-HES data. Percentages shown use the total number of individuals at the next highest level in the flow as their denominator.
Abbreviations: CPRD, Clinical Practice Research Database; HES, hospital episode statistics; OAC, oral anticoagulant; Rx, prescription; Dx, diagnosis.
Footnotes
Disclosure
SR and LM are full-time employees of Bristol-Myers Squibb, and SR is a shareholder of Bristol-Myers Squibb. CJS and MS are full-time employees of PHMR, PHMR received financial support for the work described in this manuscript from Bristol-Myers Squibb. The authors report no other conflicts of interest in this work.
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Derivation of the study population for the Cox proportional hazards regression analysis using CPRD data only. Percentages shown use the total number of individuals at the next highest level in the flow as their denominator.
Abbreviations: CPRD, Clinical Practice Research Database; HES, hospital episode statistics; OAC, oral anticoagulant; Rx, prescription; Dx, diagnosis.
Derivation of the study population for the Cox proportional hazards regression analysis using linked CPRD-HES data. Percentages shown use the total number of individuals at the next highest level in the flow as their denominator.
Abbreviations: CPRD, Clinical Practice Research Database; HES, hospital episode statistics; OAC, oral anticoagulant; Rx, prescription; Dx, diagnosis.