Fig. 1.
Overview of the association results from the genome-wide association study of CAD in UK Biobank participants of white British ancestry and with diabetes mellitus (3968 CAD cases and 11,698 controls). Each tested SNP is visualised as a dot with location on the genome shown on the x-axis and –log10-transformed p values on the y-axis. (a) Results for all chromosomes with the consensus threshold for genome-wide significance (5 × 10−8) marked with a horizontal line. (b, c) Regional (Locuszoom [7]) plots of the two loci LPA (b) and 9p21 (c). SNPs are coloured based on their correlation with the index SNP in each locus in the regional plots. Previously reported phenotypes in genome-wide association studies are annotated. CDKN2A-AS1 is also known as CDKN2A-DT. CVD, cardiovascular disease; LDL-C, LDL-cholesterol; Lp(a), lipoprotein(a); LpPLA2, lipoprotein-associated phospholipase A2; MI, myocardial infarction