Fig. 7.

Homology model of the human SGLT2 based on the inward facing, occluded conformation of vSGLT (as described in [19]). Helices are represented as tubes. For clarity, helices −1 and 11–14 have been removed and helices 1, 2 and 10 are depicted as transparent. TM3 is coloured orange. Highlighted are the residues forming the glucose-binding site and the inner and outer gates EL8a and EL8b are helices in the external loop linking TM7 and TM8. This figure is available as part of a downloadable slideset