Fig. 1.

OTX2 gene methylation and functional connectivity from ventral mPFC. a Results of connectivity conjunction analysis showing functional connectivity between the right vmPFC and bilateral regions of the medial frontal cortex and the cingulate. Greater OTX2 methylation (b) and lower depression scores (c) are associated with increased connectivity between these two brain regions. Two clusters of activation reached significance: a cluster centered within the subcallosal gyrus of the cingulate and extended into the ventral frontal medial cortex; a second cluster centered within the ventral aspect of the frontal pole, extending dorsally and posterior to the paracingulate gyrus