Table 1.
Tumor incidence and morbidity in the different mouse strains.
| Genotype | Mice (N) | Spleen weight (Mean ± SD) | Tumor Multiplicity (Mean ± SD) | Tumor Incidence | Incidence vs. Apc1638N/+ | Incidence vs. Apc1638N/+ MyD88LSL |
|---|---|---|---|---|---|---|
| Apc1638N/+ | 39 | 417 ± 294 mg | 3.4 ± 1.9 | 39 / 39 (100%) | – | P < .0001 |
| Apc1638N/+ MyD88LSL | 14 | 128 ± 83 mg | 0.7 ± 0.9 | 6 / 14 (43%) | P < .0001 | – |
| Apc1638N/+ MyD88IEC | 11 | 197 ± 114 mg | 1.7 ± 0,9 | 11 / 11 (100%) | n.s. | P = .0029 |
| Apc1638N/+ MyD88MYEL | 16 | 172 ± 133 mg | 2.1 ± 1.1 | 16 / 16 (100%) | n.s. | P = .0005 |
Tumor incidence was compared with two-sided Fisher's exact t test, data were compared to parental Apc1638N/+ mice, and Apc1638N/+ MyD88LSL animals, respectively.