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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: NanoImpact. 2018 Feb 21;11:82–91. doi: 10.1016/j.impact.2018.02.007

Figure 8.

Figure 8

The inhibition of caveolea/raft-mediated endocytosis and calcium channel prevented actin microfilaments alignment. Caveolae/raft-dependent endocytosis was inhibited by pretreating the cells with 25 μM Nystatin for 2 hours, and L-type calcium channel was blocked by pretreating the cells with 10 μM Nifedipine for 2 hours. Then cells were treated with TiO2, SiO2, PS, and GNPs at the concentrations that yield the same total surface area (8.76 μg/mL or 2.65 μg/cm2 for TiO2 NPs, 5.48 μg/mL or 1.66 μg/cm2 for SiO2 NPs, 2.18 μg/mL or 0.66 μg/cm2 for PS NPs, and 40 μg/mL or 21.96 μg/cm2 for gold NPs) for 2 hours; control was treated with fresh EGM-2. Mean ± standard deviation of the sample. Data were analyzed by ANOVA with Tukey’s post test, * denotes significant difference between comparisons, n = 20, p < 0.05.