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. 2018 Aug 21;5(4):ENEURO.0133-18.2018. doi: 10.1523/ENEURO.0133-18.2018

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Copyright © 2018 Yamagata et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Intact visually guided memory and impaired spatial memory in the Morris water maze tasks in the kinase-dead CaMKIIα (K42R)-KI mouse. A, Escape latencies in the visible platform trials, followed by the hidden platform trials in the water maze tasks in the kinase-dead CaMKIIα (K42R)-KI mouse as compared to the wild-type (WT) mouse. In the visible platform trials (left), both genotypes steadily decreased escape latencies and there was no significant difference between the genotypes. Both genotypes showed significantly shorter latency in the second and later blocks of trials than in the first block (labeled with gray vs black colors, p < 0.05, Bonferroni’s post hoc test). In the following hidden platform trials (right), latency differed significantly between the genotypes: CaMKIIα (K42R)-KI mice took longer time to reach the platform than wild-type mice did; *p < 0.05, **p < 0.01, ***p < 0.001 between the genotypes, Bonferroni’s post hoc test. Open circle, wild-type mice, n = 12; closed circle, CaMKIIα (K42R)-KI mice, n = 12. Note that the platform location was fixed for each mouse throughout the course of training. B, Probe trials performed on days 3 and 6 after training trials of the day (after 6 and 12 blocks of trials, respectively). Percentage time in each quadrant (left) and the number of center crossings of hypothetical platform locations (right) are shown; **p < 0.01, ***p < 0.001, ****p < 0.0001, Tukey’s post hoc test. Closed column, target quadrant; hatched column, left quadrant; open column, opposite quadrant; dotted column, right quadrant. C, Averaged swimming traces of each genotype for 60 s in the probe trials performed on days 3 and 6. The color indicates the average time spent at a certain location (1 × 1 cm square) per animal. The platform location was aligned in the right upper quadrant by rotation and indicated by a black-lined circle. D, Swimming speed measured for 60 s in the probe trials performed on days 3 and 6. There was no significant difference between the genotypes. Open column, wild-type mice; closed column, CaMKIIα (K42R)-KI mice.