Figure 6.

Schematic illustration showing differential involvement of kinase activity of CaMKIIα in hippocampus- and amygdala-dependent memory. Hippocampus-dependent memory is mediated exclusively by the CaMKIIα activity-dependent pathway, whereas amygdala-dependent memory is mediated not only by the CaMKIIα activity-dependent pathway, but also by a CaMKIIα activity-independent pathway, the candidate of which may include CaMKIIβ activity or de novo synaptogenesis, such as generation of multi-innervated dendritic spines (see text in detail).