Table 2.
Summary of All the Sexual Functioning Outcomes
| Bupropion (n = 36) |
Placebo (n = 36) |
Mean EOT differenceaFor bupropion vs. placebo |
95% CI for differencea |
|||||
|---|---|---|---|---|---|---|---|---|
| Baseline |
EOT |
Baseline |
EOT |
|||||
| Outcome measure | Mean ± SD | Mean ± SD | Mean ± SE | Lower bound | Upper bound | p value | ||
| CGI-SF | 5.33 ± 0.48 | 2.64 ± 1.61 | 5.25 ± 0.60 | 3.75 ± 1.59 | −0.83 ± 0.35* | −1.5 | −0.13 | .02 |
| SDI-2-BM | ||||||||
| DSD | 26.19 ± 8.59 | 36.08 ± 10.17 | 27.67 ± 8.44 | 29.99 ± 13.44 | 5.83 ± 2.78* | 0.28 | 11.37 | .04 |
| SSD | 6.22 ± 4.34 | 7.45 ± 4.97 | 5.06 ± 4.29 | 6.87 ± 5.97 | 0.58 ± 1.34 | −2.09 | 3.24 | .67 |
| Total | 41.14 ± 14.00 | 53.53 ± 15.88 | 41.06 ± 14.12 | 47.36 ± 21.09 | 5.69 ± 4.41 | −3.10 | 14.49 | .20 |
| Mal-IIEF-15 domain | ||||||||
| Erectile function | 18.14 ± 8.74 | 22.56 ± 7.69 | 17.44 ± 8.07 | 18.06 ± 9.43 | 4.51 ± 2.02* | 0.47 | 8.56 | .03 |
| Orgasmic function | 6.50 ± 3.01 | 7.30 ± 2.92 | 5.17 ± 3.31 | 5.99 ± 3.75 | 1.30 ± 0.81 | −0.33 | 2.94 | .12 |
| Sexual desire | 5.00 ± 1.41 | 6.77 ± 1.91 | 5.25 ± 1.34 | 6.04 ± 1.97 | 0.70 ± 0.44 | −0.18 | 1.59 | .12 |
| Intercourse satisfaction | 7.06 ± 3.89 | 8.78 ± 3.77 | 6.33 ± 4.01 | 6.46 ± 4.18 | 2.36 ± 0.97* | 0.44 | 4.29 | .02 |
| Overall satisfaction | 6.50 ± 2.71 | 7.10 ± 2.29 | 6.64 ± 2.11 | 7.14 ± 2.41 | 0.05 ± 0.52 | −0.99 | 1.09 | .92 |
| Total | 43.19 ± 18.23 | 52.53 ± 16.14 | 40.83 ± 16.73 | 43.81 ± 19.86 | 8.69 ± 4.24* | 0.24 | 17.15 | .04 |
| Plasma TT (nmol/L) | 7.28 ± 4.50 | 12.04 ± 8.46 | 8.07 ± 2.79 | 10.18 ± 6.25 | 0.75 ± 2.12 | −3.51 | 5.01 | .73 |
| (ng/dl) | 209.79 ± 129.68 | 346.97 ± 243.80 | 232.56 ± 80.40 | 293.37 ± 180.12 | ||||
| Plasma prolactin (μIU/ml) |
182.68 ± 91.49 | 171.15 ± 90.97 | 174.79 ± 99.22 | 170.05 ± 87.95 | 3.18 ± 26.64 | −50.34 | 56.72 | .91 |
Note. aAdjustment for multiple comparisons: Bonferroni with covariate daily methadone dosage and duration of the methadone usage. EOT = end of treatment; CGI-SF = Clinical Global Impression Scale adapted for Sexual Function; Mal-IIEF-15 = Malay version of the International Index of Erectile Function 15; SDI-2-BM = Malay version of the sexual desire inventory-2; DSD = dyadic sexual desire; SSD = solitary sexual desire; TT = total testosterone; SD = standard deviation; SE = standard error. nmol/L = nanomoles per liter; ng/dl = nanograms per deciliter; μIU/ml = macro international units per milliliter.
*
p < .05. **p < .01.