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Oncology Letters logoLink to Oncology Letters
. 2018 Aug 10;16(4):5249–5256. doi: 10.3892/ol.2018.9294

Triple primary cancer of the head and neck, skin and prostate: A case report and literature review

Nobuyuki Maruyama 1,2, Toshiyuki Nakasone 2, Osao Arakaki 3, Hirofumi Matsumoto 4, Tessho Maruyama 1,2,✉, Akira Matayoshi 2, Takahiro Goto 2, Seiichi Saito 5, Naoki Yoshimi 4,6, Akira Arasaki 1,2, Kazuhide Nishihara 1,2
PMCID: PMC6144871  PMID: 30250595

Abstract

Second primary cancer (SPC) is an important prognostic factor for patients with head and neck cancer (HNC); therefore, the association between the prognosis and development of SPC has been well-reported. The use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is valuable to examine cancer stage, evaluate treatment responses and investigate suspected relapses or metastases. In the present study, the case of a male patient who was diagnosed with three primary cancer types, including well to moderately differentiated squamous cell carcinoma (SCC) of the mandible, axillary cutaneous poorly differentiated SCC and prostate adenocarcinoma, was described. Among these, mandible cancer was the first diagnosed when the patient was 70 years of age. Synchronous skin and prostate cancer (PRC) types then developed 3 years later. To the best of our knowledge, this is the first report of the aforementioned combination of cancer types. Postoperative FDG-PET was not performed as no lesions of recurrence or metastases of mandible cancer were found. Three years later, the PRC was asymptomatic and was incidentally detected by FDG-PET performed for a preoperative evaluation of skin cancer. It was indicated that FDG-PET could be utilized in patients with HNC due to there being no accurate FDG-PET protocol to detect SPC over a long-term follow-up.

Keywords: head and neck cancer, second primary, skin cancer, prostate cancer, 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography, multiple primary neoplasms

Introduction

With progression in cancer treatment, the survival rate of patients has increased globally in 2012 (1,2). In the USA, the number of people with a cancer diagnosis was ~14.5 million in 2014 (3). Based on the Surveillance, Epidemiology and End Results (SEER) program, cancer survivors have a higher risk of second primary cancer (SPC) compared with the general population (4). Despite the medical progression achieved and the advances in locoregional control, continual SPC is one of the factors that impede the improvement of survival rate of patients with cancer (5); therefore, SPC is an important prognostic factor for patients with head and neck cancer (HNC) (6). Furthermore, SPC more frequently develops following HNC, compared with the general population (5,7). 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is primarily used to examine lymph nodes, the initial stage of HNC, treatment responses, unknown primary cancer (PCs) types and relapses or metastases (8–11); however, there is no accurate FDG-PET protocol to detect SPC over a long-term follow-up period subsequent to HNC treatment. In the present study, a rare case of triple PC, including well to moderately differentiated squamous cell carcinoma (SCC) of the mandible, axillary cutaneous poorly differentiated SCC and adenocarcinoma (AC) of the prostate, was described. The prostate tumor was incidentally detected by FDG-PET. The aim of the present study was to discuss the necessity of FDG-PET as a protocol of postoperative follow-up.

Case report

Written informed consent was obtained from the patient for the publication of this case report and the accompanying images. The report was submitted for ethical review to the Ethics Committee of the University of the Ryukyus (Okinawa, Japan), which waived the requirement for review per institutional protocol due to the study not containing content that requires ethical approval. The Ethics Committee approved the submission and publication of the manuscript.

A 70-year-old man was evaluated and treated for cancer of the right mandible in September 2012 at the Department of Oral and Maxillofacial Surgery, University Hospital of the Ryukyus (Okinawa, Japan). The disease was initially considered to be benign or an inflammation in the radiolucent area around the wisdom teeth, and the patient underwent extraction of the right third molar and curettage (with histological test) at a different clinic (Nanbu Tokushukai Hospital, Okinawa, Japan); however, the histopathological examination at this clinic demonstrated well to moderately differentiated SCC, according to the World Health Organization Classification of Tumours (12) (Fig. 1). Histopathological examination was conducted with hematoxylin and eosin staining. In brief, resected tissues were fixed in 20% formalin for ~24 h at room temperature. Subsequently, slides were washed with xylene for 9 min, then dexylened with 100, 95, 80 and 70% ethanol for 20, 10, 10 and 10 times, respectively. Slides were then stained with hematoxylin for 10 min, and washed with tap water for 3 min. Subsequently, slides were washed with 0.5% hydrochloric acid alcohol once and washed with tap water for 5 min. Following this, slides were stained with eosin for 6 min and slides were dehydrated with 95 and 100% ethanol for 10 and 40 times, respectively. Additionally, slides were immersed in xylene 30 times and cover glass was placed on the slides. All of the methods were at room temperature, and then examined using a light microscope at ×200 magnification. Subsequently, the patient was referred to the University Hospital of the Ryukyus. Physical examination indicated slight swelling of the gum around the extraction socket. No specific lesion was located in the mouth, and no palpable lymph node enlargement was evident in the head or neck region. The patient had no history of cancer and had never undergone radiation therapy or chemotherapy. Additionally, the patient had been a moderate smoker in his 20s and was a moderate drinker. The family history included gastric cancer in two brothers. The patient also suffered from well-controlled hypertension, reflux esophagitis, hyperuricemia, sensorineural hearing loss, cerebral infarction and dyslipidemia.

Figure 1.

Figure 1.

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Histological examination of the mandible tissue by hematoxylin and eosin staining. Atypical squamous cells and cancer pearls are observed in the alveolar bone of the mandible, with intercellular bridges (arrow), which are characteristics of well-differentiated squamous cell carcinoma. Magnification, ×200; scale bar, 100 µm.

Contrast-enhanced computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI) and FDG-PET were used to examine the mandible cancer stage. The CT results demonstrated bone resorption in the right mandible and tumor invasion was suspected (Fig. 2), whereas no lesions were observed in the cervical lymph nodes, lungs, bones or liver. The MRI results indicated high-signal intensity around the margins of the curettaged area; however, no other lesions were located in the head and neck region. FDG-PET was used to examine the stage of SCC and revealed increased FDG uptake [maximum standardized uptake value (SUVmax), 11.9] in the right mandible. Additionally, no other potential cancer areas were located in the rest of the body. An upper gastrointestinal endoscopy demonstrated no abnormal data. As a result, the patient was diagnosed with mandibular SCC (T4N0M0, stage IVa), according to the Union for International Cancer Control Tumor-Node-Metastasis classification, 7th edition (13).

Figure 2.

Figure 2.

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Contrast-enhanced computed tomography results indicating resorption in the right mandible and suspected tumor invasion (arrow) (axial section).

The patient received 6 cycles of bleomycin chemotherapy preoperatively (total dose, 90 mg), as described previously (14,15). In October 2012, the patient underwent segmental mandibulotomy and reconstructive grafting (non vascularized bone grafting), ipsilateral supraomohyoid neck dissection and tracheotomy. A pathological examination demonstrated SCC of the submaxilla, with venous invasion but no lymphatic invasion. Furthermore, bone invasion was present, but the surgical margins were negative. Cervical lymph nodes exhibited no evidence of cancer. Following surgery, a salivary fistula of the parotid region persisted. The patient then underwent postoperative radiation (total dose, 20 Gy in 10 fractions over ~3 weeks). Resolution of the salivary fistula using low-dose radiation therapy was attempted (16,17), and notably, the fistula was successfully resolved. Although a number of studies have reported a lower success rate of radiotherapy following the reconstruction of a non-vascularized bone graft (18,19), the radiotherapy for those patients is not contraindicated in the National Comprehensive Cancer Network guideline (20); therefore, a low-dose radiation was selected to resolve the salivary fistula of the parotid region (17). Surgical site infection did occur, and the grafted bone and titan plate were surgically removed 4 months after the implantation. Subsequently, no clinical or radiological signs of mandible cancer recurrence/metastasis or infection in the head and neck region or the lungs were observed.

The patient developed skin cancer (second type) and prostate cancer (PRC) (third type) 3 years after the mandible (first type) cancer treatment. A nodule on the left axillary cutaneous lesion was noted by the patient in July 2015. In April 2016, the nodule (18×10×7 mm in size) was resected at a different hospital (Chibana Clinic, Okinawa, Japan) and pathologically diagnosed as poorly differentiated SCC of the skin, according to the World Health Organization Classification of Tumours (21). A pathological examination demonstrated poorly differentiated SCC, with positive margins (data not shown). Pathological examination was conducted with hematoxylin and eosin staining. In brief, resected tissues were fixed in 10% formalin for ~24 h at room temperature. Subsequently, slides were washed with xylene for 15 min, then dexylened with 100, 80 and 50% ethanol for 2, 1 and 1 min, respectively. Subsequently, slides were washed with tap water for 2 min. Following this, slides were washed with distilled water for 30 sec. Slides were then stained with hematoxylin for 4 min and washed with tap water for 6 min. Additionally, slides were washed with distilled water for 30 sec. Subsequently, slides were stained with eosin for 3 min and slides were dehydrated with 100% ethanol for 4 min. Following this, slides were immersed in xylene for 8 min and cover glass was placed on the slides. All of the methods were at room temperature, and then examined using a light microscope at ×200 magnification. Subsequently, the patient was referred to University Hospital of the Ryukyus for further examination and treatment. Contrast-enhanced CT and FDG-PET were performed to evaluate the skin cancer stage. There was no accumulation in the axillary skin, axillary lymph nodes, lungs, and head and neck region; however, FDG uptake was observed in the prostate (SUVmax, 4.61) (Fig. 3). The patient had a prostate-specific antigen (PSA) level of 19.87 ng/ml (normal range, 0–3.53 ng/ml). Due to the absence of clinical symptoms of ‘non-head and neck, lung and esophagus cancer’, the PSA or carcinoembryonic antigen test was not performed prior to the PET examination of the skin cancer. Notably, the SPC incidence of this cancer type (non-head and neck, lung and esophagus cancer) is low in patients with HNC (22). Additional resection of skin (second) cancer was first performed in June 2016 at the University Hospital of the Ryukyus and poorly differentiated SCC was resected. Pathological examination was conducted with hematoxylin and eosin staining. In brief, resected tissues were fixed in 10% formalin for ~24 h at room temperature. Subsequently, slides were washed with xylene for 9 min, then dexylened with 100, 95 and 70% ethanol for 3, 1 and 1 min, respectively. Subsequently, slides were washed with tap water for 3 min. Slides were then stained with hematoxylin for 4 min, and washed with tap water for 3 min. Following this, slides were dehydrated with 95% ethanol for 1 min. Subsequently, slides were stained with eosin for 3 min and slides were washed with 95 and 100% ethanol for 2 and 8 min, respectively. Subsequently, slides were immersed in xylene for 12 min and cover glass was placed on the slides. All of the methods were at room temperature, and then examined using a light microscope at ×100 magnification (Fig. 4). Following the resection of the second cancer, a guided percutaneous needle biopsy of the prostate lesion was performed in August 2016 at the University Hospital of the Ryukyus, which indicated a diagnosis of AC (Gleason score 4+5), according to Gleason and Mellinger (23). Laparoscopic prostatectomy and pelvic lymphadenectomy was then performed for the PRC (third type) in October 2016 at the University Hospital of the Ryukyus. Pathological data demonstrated positive pT4 (bladder) invasion (Fig. 5). Pathological examination was conducted with hematoxylin and eosin staining. In brief, resected tissues were fixed in 10% formalin for ~24 h at room temperature. Subsequently, slides were washed with xylene for 9 min, then dexylened with 100, 95 and 70% ethanol for 3, 1 and 1 min, respectively. Subsequently, slides were washed with tap water for 3 min. Slides were then stained with hematoxylin for 4 min and washed with tap water for 3 min. Following this, slides were dehydrated with 95% ethanol for 1 min. Subsequently, slides were stained with eosin for 3 min and slides were washed with 95 and 100% ethanol for 2 and 8 min, respectively. Following this, slides were immersed in xylene for 12 min and cover glass was placed on the slides. All of the methods were at room temperature, and then examined using a light microscope at ×200 magnification. Negative lymphatic (D2-40) and vascular (by Victoria blue-hematoxylin and eosin staining) invasion, positive perineural (S-100) invasion and positive margins, but no lymph node metastasis was found. Victoria blue-hematoxylin and eosin staining was conducted. In brief, resected tissues were fixed in 10% formalin for ~24 h at room temperature. Subsequently, slides were washed with xylene for 9 min, and then dexylened with 100, 95 and 70% ethanol for 6, 3 and 3 min, respectively. Slides were then stained with Victoria blue overnight at room temperature, the remainder of Victoria blue was removed with 70% ethanol and then washed with tap water. Subsequently, slides were washed with xylene for 3 min, and then washed with tap water for 3 min. Following this, slides were stained with hematoxylin for 3 min. Subsequently, washed with tap water for 3 min and dehydrated with 95% ethanol 20 times. Following this, slides were stained with eosin for 3 min, and then dehydrated with 100% ethanol for 4 min. Slides were then immersed in xylene for 12 min, and cover glass was placed on the slides. All of the methods were at room temperature, and then examined using a light microscope at ×200 magnification. However, in February 2017, follow-up PSA indicated the high PSA level of 35.67 ng/ml (normal range, 0–3.53 ng/ml) was elevated, and subsequent CT and FDG-PET demonstrated recurrence of the PRC, accompanied with lymph node metastasis of the left axillary and pelvic regions, and suspected multiple liver metastases (the liver lesion was then examined by fine-needle biopsy in April 2017 and no cancerous lesions were histologically located). Axillary lymph node dissection was performed in July 2017, and the lymph nodes were histologically diagnosed as SCC metastases. The patient was treated with chemotherapy [from March 2017, docetaxel (60 mg/m2) was intravenously administered 10 times, and degarelix were administered subcutaneous injections into the abdominal region 14 times (240 mg once in March 2017 and then 80 mg 13 times)] for the liver, pelvic and prostate regions. The time between administration of the two drugs was 4 or 5 weeks. The lesions gradually diminished at the time of writing, therefore his prognosis cannot be stated, and further treatment of the chemotherapy (identical dose of docetaxel and degarelix) are planned. Based on the aforementioned lesions, the patient was diagnosed with ‘triple PCs’, according to the criteria by Warren and Gates (24), and the skin and PRCs were synchronous, according to the criteria by Moertel et al (25). The skin cancer (poorly differentiated SCC) was not considered the metastasis of the mandible cancer (well to moderately differentiated SCC), according to the criteria by Warren and Gates (24).

Figure 3.

Figure 3.

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Preoperative use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (axial section). Metabolic activity was detected in the prostate (maximum standardized uptake value, 4.61) (arrow).

Figure 4.

Figure 4.

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Histological examination of the skin tissue by hematoxylin and eosin staining. Irregular nests and cords composed of atypical squamous cell without keratinization infiltrate the dermis and subcutaneous tissue, and spindle-shaped cells are observed (arrow), which are characteristics of poorly differentiated squamous cell carcinoma. Magnification, ×100; scale bar, 100 µm.

Figure 5.

Figure 5.

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Histological examination of the prostate tissue by hematoxylin and eosin staining. Solid strands without glandular lumina invade the stroma (arrow). Magnification, ×200; scale bar, 100 µm.

Discussion

There are two important points in the present report: Firstly, to the best of our knowledge, the combination of triple PCs (well-differentiated SCC of the mandible, axillary cutaneous poorly differentiated SCC and prostate AC) has not been previously reported; secondly, to detect SPC, we suggest that FDG-PET should be used for the long-term follow-up of patients with HNC.

Based on the aforementioned lesions, the patient in the present case was diagnosed with triple PCs according to the criteria suggested by Warren and Gates in 1932 (24), and the skin and PRCs were synchronous according to the criteria defined by Moertel et al in 1961 (25). A systematic literature search of PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and Google Scholar (https://scholar.google.co.jp/) articles published between 1932, when the SPC criteria was firstly defined (24), and 2017 was performed. The databases were searched using the following terminological combinations (one term used from each category): i) Any region of the head and neck, including oral cavity, oral, mouth, oral floor, tongue, lip, soft plate, gingiva, buccal, maxillary, mandibular, tonsil, neck, face, cheek, salivary grand, parotid gland, sublingual gland, submandibular gland, nose, nasal cavity, paranasal sinus, nasopharynx, larynx, oropharynx, mesopharynx, hypopharynx, glottis, thyroid, ear; ii) prostate; and iii) SPC terms, including second primary cancer, second primary malignancy, second primary tumor, multiple primary cancer, multiple primary neoplasm, multiple primary malignancies, multiple primary malignant, triple primary, triple cancer, quadruple primary, quadruple cancer, quintuple primary, quintuple cancer, sextuple primary, sextuple cancer, septuple primary, septuple cancer, octuple primary, octuple cancer, nonuple primary, or nonuple cancer. A report containing more than decuple primary cancer types, including PRC, could not be located. English articles were then searched using the aforementioned terms. This resulted in the identification of 23 cases of patients with multiple (triple or more) cancer types, including HNC and PRC (25–39) (Table I). The study by Gordon (26) was located by non-systematic literature research, using Google Scholar and the term ‘synchronous primary carcinoma.’ However, the current combination was not found. The most frequent sites of incident of SPC following HNC are the head and neck again, the lungs and the esophagus (7,22); while SPC of the skin or prostate is uncommon. Although a number of risks of SPC have been suggested to date, the risk of SPC is unclear (40). As the combination of triple PCs in the present study was unique, the risk factors may have included the administration of preoperative chemotherapy (41) and radiation postoperatively for index mandible cancer (41,42), the fact that the patient was a current drinker (41,43), a family history of gastric cancer in two brothers (44) and finally, the patient being a former smoker (43,45). The association between being a former smoker and secondary cancer risk in cancer survivors is unclear in the present case due to the cessation of smoking more than 40 years previously. Shiels et al (45) demonstrated that being a former smoker resulted in a higher SPC risk compared with the risk for those who had never smoked. Based on the aforementioned data, all factors for SPC risk in the current case should be carefully considered. Rose et al (6) analyzed 34,568 patients with non-metastatic SCC of HNC, based on SEER data, and reported that patients with HNC are at a high risk of SPC. The 5-year cumulative all-cause fatality rate, HNC-specific fatality rate, SPC fatality rate and non-cancer fatality rate were 51.3, 23.8, 14.6 and 13.0%, respectively. Additionally, the 10-year cumulative rate of SPC mortality reached 20% (6). As a result, mortality due to SPC is high and persistent over a long term, and contributes to the poor prognosis of SCC in patients with HNC (6). Other previous studies have also indicated that even in long-term cancer survivors, SPC following HNC poses a high risk (39,42,46). Furthermore, SPC more frequently develops in various sites in patients with HNC, compared with the SPC occurrence of the general population (5,7); therefore, clinicians should give more focus to SPC following HNC treatment, and a more accurate protocol should be established.

Table I.

Cases exhibiting triple or greater primary cancer of multiple types, including head and neck, and prostate cancer.

Order of sites exhibiting the occurrence of multiple primary cancer
Author (year) First Second Third Fourth Fifth Sixth (Refs.)
Gordon (1948) PRC Lung Thyroid (26)
Goodner and Watson (1956) Soft plate Esophagus PRC (27)
Moertel et ala (1961) Colon Lip PRC (25)
Kidney Mouth PRC (25)
Lip Lung PRC (25)
Lung PRC Thyroid (25)
Lip Skin PRC (25)
Mouth Mouth PRC (25)
Lip Mouth PRC (25)
Bittorf et al (2001) PRC Colorectum Oral cavity (28)
Thyroid UB PRC (28)
Rho et al (2002) Vocal cord Bowen's disease PRC Laryngeal (29)
Rai et al (2007) PRC Kidney Thyroid (30)
Jaudah et al (2008) Thyroid PRC Renal (31)
Yamashita et al (2010) PRC Gastric Laryngeal (32)
Salem et al (2012) PRC Nasopharyngeal Lung (33)
Renal Nose Auricle PRC Colon (33)
Guven et al (2014) Bladder PRC Thyroid (34)
Mukaiyama et al (2014) Glottis Renal pelvis UB Oral floor PRC Esophagus (35)
Mohammed et al (2015) PRC UB Thyroid (36)
Testori et al (2015) Lung Oropharynx Large bowel PRC (37)
Pastore et al (2015) Kidney Oropharynx PRC (38)
Adel et al (2016) Buccal Lip Gum PRC (39)
Present case Mandible Axillary skin PRC –
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a

Order of incidence was unknown. PRC, prostate cancer; UB, urinary bladder.

We suggest that FDG-PET could be used for detecting SPCs in the long-term follow-up of patients with HNC. To date, there is no accurate protocol of FDG-PET for the follow-up of patients with HNC. In the present case, PRC (third type) was determined during the preoperative FDG-PET for skin (second type) cancer. The PRC (third type) was not determined during the first follow-up period of 3 years, between the mandible (first type) cancer treatment and the skin (second type) cancer occurrence. Contrast-enhanced CT was performed from the head to the lungs routinely during the follow-up subsequent to the HNC treatment; if FDG-PET had been performed as a routine follow-up tool of mandible cancer, the PRC may have been detected earlier. Cancer of the oral cavity and skin are relatively simple to detect due to the lesions being observed directly. Conversely, as PRC is asymptomatic in the early stages (47) and is an internal disease, it is frequently incidentally detected. In order to confirm the diagnosis method of PRC of those patients, the cases in Table I were further reviewed and the manner in which the subsequent PRC was detected is indicated (28,29,31,33–35,37,38) (Table II). Of the 9 patients in which PRC was diagnosed, including the present case, PRC was detected by a serum test in 2, incidentally by surgery of the other tumor in 2, by FDG-PET in 2 and by clinical symptoms in 1 (PRC detection in 2 patients was not described). Similar to the present case, Testori et al (37) incidentally detected lung cancer using FDG-PET (37). Notably, among the cases in Table II, 5/7 patients presented with no subjective symptoms of PRC and were incidentally diagnosed with cancer. Additionally, in the SEER study, the incidence of secondary PRC within 1 year of HNC was only 0.3% among 26,258 male patients with oral and pharyngeal (tongue, mouth, tonsil, oropharyngeal and hypopharyngeal) cancer (4).

Table II.

Method of detecting subsequent PRC from cases of Table I.

Author (year) Interval between first cancer and subsequent PRC Method of detecting PRC Subjective symptoms of PRC (Refs.)
Bittorf et al (2001) 11 years NA NA (28)
Rho et al (2002) 3 years Serum tumor marker test to rule out hidden cancer following the diagnosis of Bowen's disease None (29)
Jaudah et al (2008) 10 years Urinary symptom Urinary symptom (31)
Salem et al (2012) 5 years NA NA (33)
Guven et al (2014) Simultaneous Incidentally determined in BC surgery Hematuria and frequent urination, which were considered to be a result of BC (34)
Mukaiyama et al (2014) 3 years 9 months Incidentally determined in recurrent BC surgery None (35)
Testori et al (2015) Simultaneous Incidentally detected by FDG-PET for suspected lung cancer None (37)
Pastore et al (2015) 7 months Serum tumor marker test for follow-up after kidney cancer treatment None (38)
Present case 3 years 8 months Incidentally detected by FDG-PET to determine the preoperative axillary cancer staging None –
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PRC, prostate cancer; NA, not applicable; BC, bladder cancer; FDG-PET, 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography.

Patients with cancer should be carefully followed up in order to detect SPC for the following reasons: i) patients with cancer have a higher risk for SPC a long time period after PC compared with the general population (42); ii) as aforementioned, SPC more frequently develops in various sites in the body following HNC (5,7); iii) PRC should be detected at an early stage when it is asymptomatic, due to this condition demonstrating a poor prognosis at advanced stages (48) [for patients with localized stage PRC, the 5-year relative survival rate is ~100%; by contrast, for patients with advanced (distant) stage PRC, the rate declines to 28% (49)]; and iv) PRC accounted for ~20% of new cancer cases in males in the USA in 2016 (50). In the USA, among males, the most prevalent cancer in 2016 was PRC, which was recorded in 3.3 million cases (49); therefore, long-term follow-up to detect PRC following HNC treatment is required. Yamashita et al (43) routinely performed FDG-PET/CT scans once every 6–12 months for 5 years in the follow-up period following the initial cancer treatment of 434 patients with newly diagnosed HNC, and determined that 12% of patients had synchronous SPC and 24% of patients had metachronous SPC. It is important to utilize FDG-PET for screening SPC during follow-up of HNC, as well as during preoperative cancer staging (43,51). Compared with CT or MRI, PET/CT has the advantage of evaluating SPC not only at initial staging of first HNC (51), but also postoperative follow-up, similar to the present case, due to PET/CT can evaluate the entire body range; however, there is no accurate protocol for detecting SPC for the long-term follow-up of HNC to date. FDG-PET/CT has an important role in the management of patients with HNC, in order to diagnose long-term surveillance of recurrence or metastasis (11). For patients with HNC, FDG-PET/CT is generally performed at ≥6 months after the initial therapy (11); however, there are numerous studies regarding PET/CT that have reported a range of follow-up periods (9,36,43,52), indicating that the optimal follow-up period has yet to be defined. In the present case, second primary PRC was detected 3 years after the initial HNC. Although PET/CT can be performed for extended follow-ups, it has certain disadvantages and risks, including the following: The scan may provide false-positive results (9); patients with diabetes mellitus cannot undergo PET/CT (53); PET/CT sensitivities depend on the body site (54); and finally, inflammatory lesions, metal artifacts or benign lesions can cause difficulties in performing PET/CT (55). Furthermore, the complications caused by the exposure to X-rays whilst performing PET/CT should be considered (53). Additionally, the decision to perform the examination differs among nations, indicating that clinicians should consider the characteristics of the health care system of each country.

There are several limitations in the present study, including the fact that the conclusions are based on a single case report, which limits the generalizability, and that the present combination of triple cancer was researched using PubMed and Google scholar, which are major search services, but other search engines were not used. For the present case, further studies may provide beneficial information for detecting SPCs, including PRC, following the treatment of HNC.

In conclusion, a rare case of triple PCs was described in the present study. We suggest that FDG-PET should be performed to detect hidden SPC, such as PRC, for the long-term follow-up of patients with HNC, particularly in cases where risk factors are present. SPC should be detected early in order to maximize positive patient outcomes.

Acknowledgements

The authors would like to thank Professor Kenzo Takahashi from the Department of Dermatology, Graduate School of Medicine, University of the Ryukyus (Okinawa, Japan) for his advice.

Glossary

Abbreviations

SPC

second primary cancer

FDG-PET

2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography

SEER

Surveillance, Epidemiology and End Results

HNC

head and neck cancer

PC

primary cancer

SCC

squamous cell carcinoma

AC

adenocarcinoma

CT

computed tomography

MRI

magnetic resonance imaging

SUVmax

maximum standardized uptake value

PSA

prostate-specific antigen

PRC

prostate cancer

Funding

No funding was received.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Authors' contributions

NM and TM acquired the data, performed the literature review and edited the manuscript. AA substantially contributed to the concept and design of the study. TN, OA, AM, TG, SS and KN acquired the data and contributed clinical advice. HM and AA revised the manuscript. HM and NY evaluated the specimens and gave histopathological advice. TM had a major role in writing the manuscript.

Ethics approval and consent to participate

The report was submitted for ethical review to the Ethics Committee of the University of the Ryukyus (Okinawa, Japan), which waived the requirement for review per institutional protocol due to the study not containing content that requires ethical approval. The Ethics Committee approved the submission and publication of the manuscript. Written informed consent was obtained from the patient for the publication of this case report and the accompanying images.

Patient consent for publication

Written informed consent was obtained from the patient for the publication of this case report and the accompanying images.

Competing interests

The authors declare that they have no competing interests.

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