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. 2017 Dec 18;22(12):2251. doi: 10.3390/molecules22122251

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of diosmin on high glucose-induced mitochondrial dysfunction in ARPE-19 cells. (A) Levels of cytochrome c in the cytosolic fraction or mitochondrial fractions were determined by ELISA kit; (B) The activity of caspase-3 in the cell lysate was measured using a colorimetric caspase-3 assay kit; (C) Apoptosis index was measured by detection of DNA fragmentation with the Cell death detection ELISA kit. Each column represents means ± SD (n = 5 per group). ^a p < 0.05 and ^b p < 0.01 compared with normal-glucose vehicle-treated group (control), respectively. ^c p < 0.05 and ^d p < 0.01 compared with high-glucose vehicle-treated group, respectively.