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. 2018 Feb 1;14(1):1–12. doi: 10.1080/15476278.2018.1423931

FIGURE 4.

FIGURE 4.

Comparison of hepatic functions between the 2D culture dish and 3D alginate architecture. (A). The expression of Albumin, ASGR1, CK18 and CYP1A2 genes gradually increased in primary hepatocytes cultured with hMSCs in a 3D hepatic structure. Gene expression continued for at least 7 days. MEF, mouse embryonic fibroblasts. *P < 0.05, **P < 0.01, ***P < 0.001. Data are mean ± SD. (B). Mouse Albumin secretion was measured in the cultured medium at day 1, 3, and 7. *P < 0.05, **P < 0.01. Data are mean ± SD. (C). Urea synthesis level at day 7 in hepatocytes cultured in 2D, 3D and 3D with MSCs. **P < 0.01, ***P < 0.001. Data are mean ± SD.