Table 5.

Effects of SGI on pharmacokinetic parameter of chlorzoxazone (4.0 mg/kg).

Parameters	BCG	Treatment Groups
		7D-G	14D-G
AUC(0–t)(mg/L·h)	19.23 ± 2.72	21.49 ± 1.82	21.56 ± 2.21
AUC(0–∞)(mg/L·h)	20.45 ± 2.81	23.05 ± 2.54	23.26 ± 2.55
MRT(0–t)(h)	2.45 ± 0.18	2.50 ± 0.23	2.67 ± 0.33
MRT(0–∞)(h)	3.11 ± 0.14	3.28 ± 0.80	3.49 ± 0.62
t1/2(h)	2.44 ± 0.06	2.68 ± 0.82	2.72 ± 0.39
CL(L/h/kg)	0.20 ± 0.03	0.18 ± 0.02	0.17 ± 0.02
Vd(L/kg)	0.70 ± 0.12	0.67 ± 0.15	0.68 ± 0.12

BCG, blank control group (0.9% sodium chloride solution for 10 days); 7D-G, short-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 7 days); 14D-G, long-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 14 days). Values are represented as mean ± SD (n = 6).