Table 2.
Antimicrobial activity of VIP and its analogues. Microorganisms used were E. coli ATCC 25922 and S. aureus ATCC 25923. Cecropin P1 and blank (virgin media) were used as positive and negative controls.
| Pathogen | E. coli ATCC 25922 | S. aureus ATCC 25923 | ||
|---|---|---|---|---|
| Compound | MIC a | MBC b | MIC | MBC |
| VIP1 c | 64 | 128 | >256 | >256 |
| VIP2 | 16 | 32 | 64 | 128 |
| VIP3 | >256 | >256 | >256 | >256 |
| VIP4 | >256 | >256 | >256 | >256 |
| VIP5 | >256 | >256 | >256 | >256 |
| VIP6 | >256 | >256 | >256 | >256 |
| VIP7 | 8 | 8 | 16 | 32 |
| VIP8 | 2 | 4 | 2 | 4 |
| Cecropin P1 | 2 | 4 | 8 | 8 |
a MIC means minimum inhibitory concentration in μM; b MBC means minimum bactericidal concentration in μM; c VIP1 is the natural vasoactive intestinal peptide.