Glucose Tolerance Test. (A) Intraperitoneal glucose tolerance (2g/kg) in wild-type mice treated with control antibody (n = 10), wild-type mice treated with XMetD (n = 10), SUR-1
−/− mice treated with control antibody (n = 10), SUR-1
−/− mice treated with XMetD (n = 10). # P = 0.005 SUR-1
−/− control vs. SUR-1
−/− XMetD (B) Insulin secretion in response to an i.p. glucose load (2g/kg) in in wild-type mice treated with control antibody (n = 10), wild-type mice treated with XMetD (n = 10), SUR-1
−/− mice treated with control antibody (n = 10), SUR-1
−/− mice treated with XMetD (n = 10). # P≤0.002 SUR-1
−/− control vs. SUR-1
−/− XMetD; ^ P≤0.002 wild-type control vs. wild-type XMetD.