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(A) Overall structure of the Pol II-EC [2]. Transcription factors are removed in the right panel to show the internal nucleic acids. (B) Structural transition from the preinitiation complex to the elongation complex. Left: Preinitiation complex (closed form), based on PDB 5FZ5 [17]. Middle: Initial transcribing complex, based on PDB 4V1N [16]. Right: Pol II EC [2]. The TFIIF dimerization domain and Spt5 KOW4 are removed for clarity.
