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. Author manuscript; available in PMC: 2018 Sep 23.
Published in final edited form as: ChemMedChem. 2016 Oct 5;11(21):2410–2421. doi: 10.1002/cmdc.201600417

Figure 5.

Figure 5

3D structures of A) sunitinib and compound 1a, and B) sunitinib and 1b in complex with VEGFR-2. The structure of the VEGFR-2–sunitinib complex was obtained from PDB ID: 4AGD. The protein is depicted in ribbon representation colored in green and was rendered as a surface representation. Pictures were generated using Chimera. Compounds are shown in capped stick representation and colored as follows: A) sunitinib in gold, 1a in dark grey; B) sunitinib in gold, 1b in red/salmon. For both derivatives, the oxindole core is clearly outside the protein binding pocket.