Table 1.

Stability and NTR activation of compounds 1a, 1b, and 2a–2c.

Compd	Stability [%][a]	NTR activation[b]
		$t_{\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$2$}\right.}$ [min]	Amount of substrate after 15 min [%]	Product and amount after 25 min
1a	14	<1	0	sunitinib, 93%
1b	4	<6	10	sunitinib, 58%
2a	88	<6	10	erlotinib, 44%
2b	90	–	100	–
2c	76	<6	0	2b, 90%

^[a]Aqueous stability of compound solutions (2.5 μm) after 24 h in phosphate buffer (10 mm, pH 7.4, 37°C), determined by HPLC.

^[b]Reduction and subsequent fragmentation of compounds (2.5 μm) in phosphate-buffered solutions by incubation with NADH (50 μm) and NTR (1.33 μg mL^-1) at 37°C, calculated from the HPLC chromatogram peak areas as a function of time.