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. 2017 Aug 20;22(8):1381. doi: 10.3390/molecules22081381

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Lineweaver-Burk plots for the inhibition of hMAO-A by compound 2b. [S], substrate concentration (μM); V, reaction velocity (nmol/min/mg protein). Inhibitor concentrations (IC₅₀/2, IC₅₀, and 2 × IC₅₀) are shown at the left along with negative control. K_m values from IC₅₀/2 to control; 2.831, 3.398, 5,014 and 0.940 (μM). V_max value of the competitive inhibition; 79.360 ± 5.704 (nmol/min/mg protein). (B) Secondary plot for calculation of steady-state inhibition constant (K_i) of compound 2b. Equation corresponding to the line at this graph is y = 1.1939x + 0.0127, R² = 0.9915. K_i was calculated as 0.011 μM.