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. 2017 Jul 14;22(7):1180. doi: 10.3390/molecules22071180

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Resveratrol restored Slc2a4 mRNA and GLUT4 protein expression in skeletal of T2DM mice. Slc2a4 mRNA (A); GLUT4 protein (B), and nuclear SIRT1 protein (C) were analysed in gastrocnemius skeletal muscle of non-diabetic (ND), type 2 diabetic (T2DM), and resveratrol-treated type 2 diabetic (T2DMR) mice. In (A), Slc2a4 mRNA was normalized by Atp5b mRNA (ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide); In (B,C), representative images of GLUT4 and SIRT1 proteins and respective Ponceau-stained membranes are shown. Data are expressed as mean ± SEM of 5–7 animals, and were analysed by one-way ANOVA with the Newman-Keuls post-test. * p < 0.05 and *** p < 0.001 vs. ND; # p < 0.05, and ## p < 0.01 vs. T2DM.