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IC50, Ki and mode of inhibition for compounds 1–4 on PTP1B.
| Compound | IC50 (µM) | Ki (µM) | Mode of Inhibition |
|---|---|---|---|
| Isoderrone (1) | 22.7 ± 1.7 | 21.3 ± 2.8 | Non-competitive |
| Derrone (2) | 12.6 ± 1.6 | 7.9 ± 1.9 | Non-competitive |
| Alpinumisoflavone (3) | 21.2 ± 3.8 | 14.3 ± 2.0 | Non-competitive |
| Mucusisoflavone B (4) | 2.5 ± 0.2 | 3.0 ± 0.5 | Non-competitive |
| RK682 a | 10.4 ± 1.6 | n.t. | n.t. |
n.t.: not tested. Values are expressed as mean ± standard deviation (n = 3). a Positive control.
