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. 2017 May 24;22(6):869. doi: 10.3390/molecules22060869

Table 1.

Suggestions of biological activities for flavone at Pa > 78.7%—second analysis by PASS online tool.

PA PI Activity
0.952 0.001 Inhibitor of 4-nitrophenol 2-monooxygenase
0.952 0.003 HIF1A expression inhibitor
0.947 0.004 Agonist of membrane integrity
0.943 0.002 Inhibitor 27-hydroxycholesterol 7α-monooxygenas
0.938 0.002 Kinase inhibitor
0.933 0.002 Inhibitor of colestanetriol 26-monooxygenase
0.929 0.003 Anaphylatoxin receptor antagonist
0.914 0.003 Inhibitor of membrane permeability
0.913 0.004 Chlordecone reductase inhibitor
0.913 0.009 CYP2C12 substrate
0.903 0.002 CYP2B5 substrate
0.895 0.002 Aryl-alcohol dehydrogenase (NADP+) inhibitor
0.893 0.002 CYP1A2 inducer
0.874 0.014 Aspulvinone dimethylallyltransferase inhibitor
0.872 0.002 Inhibitor of P-benzoquinone reductase (NADPH)
0.857 0.004 Inhibitor of 2-dehydropantoate 2-reductase
0.857 0.006 Aldehyde oxidase inhibitor
0.854 0.003 CYP1A inducer
0.850 0.012 Methylenetetrahydrofolate reductase inhibitor (NADPH)
0.849 0.004 Vasoprotector
0.848 0.002 CYP2A4 substrate
0.829 0.002 Quercetin 2.3-dioxygenase inhibitor
0.829 0.002 Inhibitor of Leukotriene-B4 20-monooxygenase
0.820 0.005 Inhibitor of complement factor D
0.819 0.005 Alkane 1-monooxygenase inhibitor
0.814 0.003 CYP2A11 substrate
0.813 0.018 CYP2J substrate
0.813 0.022 Testosterone 17beta-dehydrogenase (NADP+) inhibitor
0.809 0.002 CYP1A1 inducer
0.807 0.003 MAP kinase stimulant
0.806 0.006 Inhibitor of oxidoreductase
0.804 0.005 Peroxidase inhibitor
0.803 0.003 Total ecdysone 20-monooxygenase inhibitor
0.801 0.004 Inhibitor of Pin1
0.800 0.018 mucous membrane protector
0.795 0.004 Antimutagenic
0.787 0.006 Inhibitor of nitrate reductase (cytochrome)

Pa = (probability “to be active”), Pi = (probability “to be inactive”).