Table 1.
Abilities of the MeOH extract of Epimedium koreanum and its fractions to inhibit protein tyrosine phosphatase1B (PTP1B) and α-glucosidase.
| Sample | Yield (g) | IC50 (μg/mL) a | |
|---|---|---|---|
| PTP1B | α-Glucosidase | ||
| MeOH extract | 665.2 | 18.83 ± 0.14 | 120.75 ± 3.06 |
| CH2Cl2 fraction | 56.94 | 3.51 ± 0.05 | 47.69 ± 0.32 |
| EtOAc fraction | 78.20 | 27.09 ± 0.30 | 75.87 ± 0.38 |
| n-BuOH fraction | 237.12 | 14.44 ± 0.68 | 138.90 ± 0.02 |
| H2O fraction | 268.06 | 38.36 ± 1.29 | 310.01 ± 1.29 |
| Ursolic acid b | - | 5.54 ± 0.13 | |
| Acarbose b | - | 87.83 ± 1.08 | |
a The 50% inhibitory concentration (IC50) values (μg/mL) were calculated from a log dose inhibition curve and are expressed as mean ± standard error of the mean (SEM) of triplicate experiments. b Used as positive control.